Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has
become increasingly apparent that the senescence response is a complex phenotype,
which has a variety of cell non-autonomous effects. The senescence-associated secretory
phenotype, or SASP, entails the secretion of numerous cytokines, growth factors and
proteases. The SASP can have beneficial or detrimental effects, depending on the …