Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—effects of proliferative senescence
N Sitte, K Merker, T von Zglinicki, T Grune… - The FASEB …, 2000 - Wiley Online Library
Oxidized and cross‐linked proteins tend to accumulate in aging cells. Declining activity of
proteolytic enzymes, particularly the proteasome, has been proposed as a possible
explanation for this phenomenon, and direct inhibition of the proteasome by oxidized and
cross‐linked proteins has been demonstrated in vitro. We have further examined this
hypothesis during both proliferative senescence (this paper) and postmitotic senescence
(see the accompanying paper, ref 1) of human BJ fibroblasts. During proliferative …
proteolytic enzymes, particularly the proteasome, has been proposed as a possible
explanation for this phenomenon, and direct inhibition of the proteasome by oxidized and
cross‐linked proteins has been demonstrated in vitro. We have further examined this
hypothesis during both proliferative senescence (this paper) and postmitotic senescence
(see the accompanying paper, ref 1) of human BJ fibroblasts. During proliferative …