Now that Cable is non-lobotomized once more, he and Deadpool return to Providence. There is a murder, however, and Deadpool attempts to solve it. The problem? He's the one who did it; he just can't remember the murder itself or why he did it. A fracture develops in their friendship, and Cable kicks Deadpool off Providence because he can't be trusted.

Deadpool hunts down Black Box, because he wants to find a way that he can be killed. While receiving "treatment" from Black Box, Deadpool is implanted with the desire to kill the "greatest threat" in the world - Cable. He doesn't now this at the time, and he's quickly reunited with his old flame, Siryn (as well as Cannonball), in an attempt to track down Cable, who has yet again gone missing. They bounce through several different alternate worlds, each of them showing what could have happened if a different part of Nathan's personality (rage, peace, and the TO mesh) had become dominant and taken over the world.

Eventually, they find a baby Cable in the hands of Mr. Sinister. Deadpool cannot leave the baby to be raised by Sinister, and so he steals him and takes him back to the 616verse. Turns out that this is the "real" Cable, anyway. But then Deadpool wants to kill him. Unable to stop this impulse, Deadpool ends up shooting himself in the head. In the end, Cable decides to burn out his power by healing Deadpool of the mental lapses and brain damage he's had for a long time, in effect saving them both.

Wow, that is a long summary. These issues are crammed with information, and if you're not a long-time X-fan, some of it might go over your head. This collection also suffers a little from the crossovers (something with the X-Men, which is why Cable disappears in the first place, as well as a tie-in with House of M). But, altogether, this is still a fun read, and not too difficult to follow as long as you don't get bogged down in the minutiae. ( )