After a devastating plague, Yorick Brown is the last man left alive in a world of women. On the run from Amazon extremists who would be happy to see him dead, his friends leave him in the care of Agent 711. But 711 is not the tragic woman she seems to be and Yorick is propelled into a drug-fueled nightmare of blood and sadism.

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After a devastating plague, Yorick Brown is the last man left alive in a world of women. On the run from Amazon extremists who would be happy to see him dead, his friends leave him in the care of Agent 711. But 711is not the tragic woman she seems to be and Yorick is propelled into a drug-fueled nightmare of blood and sadism. Collects issues #18-23 of the runaway hit Vertigo series by Brian K. Vaughan (EX-MACHINA, RUNAWAYS) and Pia Guerra.

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Yorick Brown, the last man on Earth, finds himself fighting for survival when he is placed in the care of retired government agent 711 in the backcountry of Colorado while his companions, cloning specialist Dr. Allison Mann and government agent 355, go in search of antibiotics for Brown's monkey Ampersand, the planet's only other living male.

It's 2002, and a plague of unknown origin has killed all of the male mammals on Earth-all except an amateur escape artist named Yorick Brown and his surly helper monkey, Ampersand. As the last remaining & -chromosome carriers on the planet, Yorick and his pet hold the fate of humanity in their hands.

Earth's sole surving male, 22-year-old Yorick Brown and his pet monkey, Ampersand, continues his journey to San Francisco with Dr. Alison Mann cloning specialist.

Yorick Brown, the last man on Earth, and his companions, Dr. Allison Mann and government agent 355, are on their way to California. Before they can continue on their way, however, they have to get some antibiotics for Ampersand, Yorick's monkey and the planet's only other living male.

Guided by the outstanding writing talents of Brian K. Vaughan (Swamp Thing, Ultimate X-Men) and rising star artist Pia Guerra, this acclaimed, genre-busting and controversial series continues apace After a devastating plague, Yorrick Brown is the last man left alive in a world of women. On the run from Amazon extremists who would be happy to see him dead, his friends leave him in the care of Agent 711. But 711 is not the tragic woman she seems to be and Yorrick is propelled into a drug-fuelled nightmare of blood and sadism. Stretching the graphic novel envelope again, the fourth volume in the series shows why this title continues to be held in such high regard.

“Now more than halfway across the country, Earth’s sole surviving human male, Yorick Brown, and his companion, cloning specialist Dr. Allison Mann and government agent 355, are preparing for the final leg of their journey to San Francisco, where Dr. Mann’s most important experiment awaits. But before they can leave, they need to get antibiotics for the planets only other living male—Yorick’s monkey, Ampersand. For Yorick, that means an enforced stay in the back country of Colorado with one of 355’s former associates, the retired agent 711. But Yorick is in for much more than a quiet weekend in the woods. Of all the dangers that he’s faced in his travels, what awaits him in 711s small cabin will be the hardest to confront—and will also prove to be the difference between life and death for the world’s last man.” – Page 4 of cover.

When a plague of unknown origin kills every mammal with a Y chromosome, Yorick Brown discovers that he is the only male left and embarks on a transcontinental journey to discover why.

Part 4 in the ongoing story of Yorick Brown, the only male survivor in a post-apocalyptic world populated only by women.

Yorick, Ampersand, Agent 355 and Dr. Allison Mann are preparing for the final leg of their journey to San Francisco where Dr. Mann's experiment awaits. But before they can leave, they need to get antibiotics for Ampersand. For Yorick, that means an enforced stay in the back country of Colorado with one of 355's former associates. But Yorick is in for much more than a quiet weekend in the woods. Of all the dangers that he's faced in his travels, what awaits him in the small cabin will be the hardest to confront -- and will also prove to be the difference between life and death for the world's last man.

Earth's sole surviving male, Yorick Brown, and his companions are preparing for the final leg of their journey-- where important experiments await. An enforced stay in the Colorado back country will prove to be the difference between life and death for the world's last man.

YA. Graphic novel. In the summer of 2002, a plague of unknown origin destroys every last sperm, fetus, and fully developed mammal with a Y chromosome.

Y: The Last Man, Vol. 4: Safeword by Brian K. Vaughan (2004)