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Bioengineering
Special Issues
New Strategies for Cardiac Tissue Repair and Regeneration
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New Strategies for Cardiac Tissue Repair and Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 5241

Special Issue Editors

Dr. Rajeev J. Kant

E-Mail Website
Guest Editor
School of Engineering, Brown University Center for Biomedical Engineering, Providence, RI 02912, USA
Interests: regenerative medicine; cardiac tissue engineering; vascularization; angiogenesis; biofabrication
Dr. Arvin Soepriatna

E-Mail Website
Guest Editor
School of Engineering, Brown University Center for Biomedical Engineering, Providence, RI 02912, USA
Interests: regenerative medicine; cardiac tissue engineering; cardiac imaging; arrhythmia; biomechanics
Dr. Bum-Rak Choi

E-Mail Website
Guest Editor
Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI 02903, USA
Interests: cardiac arrhythmias; optical mapping; electrophysiology; long QT syndrome; ventricular fibrillation; atrial fibrillation; cardiotoxicity; cardiac engineered microtissues

Special Issue Information

Dear Colleagues,

The heart is one of the least regenerative organs in the body, necessitating innovative interventional therapies to restore cardiac function following injury or disease. Research in cardiac tissue engineering seeks to develop, evaluate, and implement interdisciplinary strategies for repairing the heart.

In this Special Issue of Bioengineering entitled “New Strategies for Cardiac Tissue Repair and Regeneration”, we aim to organize a collection of emerging technologies and translational research that will lead to impactful medical breakthroughs in cardiovascular medicine.

All original research articles and select invited reviews are welcome in this Special Issue. Topics of interest include, but are not limited to, the following:

  • Human pluripotent stem cell differentiation of cardiomyocytes, cardiac progenitor cells, valve cells, cardiac fibroblasts, cardiac endothelial cells, and other cardiovascular-specific subtypes.
  • Transdifferentiation of cardiac fibroblasts into cardiomyocytes.
  • Biofabrication techniques of engineered cardiac tissues.
  • Cardiac biomechanics.
  • Computational cardiophysiology.
  • Cardiotoxicity testing.
  • Arrhythmia and electrical coupling.
  • Cardiac vascularization.
  • Tissue engineered vascular grafts for cardiac applications.
  • Heart valve repair.
  • Cardiac delivery of exosomes, RNAs, or other biologics.
  • In vitro microphysiological models of cardiac tissue and disease.
  • Preclinical applications of cardiovascular research technologies.

We look forward to receiving your valuable contributions.

Dr. Rajeev J. Kant
Dr. Arvin H. Soepriatna
Dr. Bum-Rak Choi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac regenerative medicine
  • cardiac tissue engineering
  • translational therapeutics
  • cardiac function
  • cardiovascular disease
  • stem cell
  • differentiation

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Review

24 pages, 2739 KiB  
Review
Bridging the Gap: Advances and Challenges in Heart Regeneration from In Vitro to In Vivo Applications
by Tatsuya Watanabe, Naoyuki Hatayama, Marissa Guo, Satoshi Yuhara and Toshiharu Shinoka
Bioengineering 2024, 11(10), 954; https://doi.org/10.3390/bioengineering11100954 - 24 Sep 2024
Viewed by 2055
Abstract
Cardiovascular diseases, particularly ischemic heart disease, area leading cause of morbidity and mortality worldwide. Myocardial infarction (MI) results in extensive cardiomyocyte loss, inflammation, extracellular matrix (ECM) degradation, fibrosis, and ultimately, adverse ventricular remodeling associated with impaired heart function. While heart transplantation is the [...] Read more.
Cardiovascular diseases, particularly ischemic heart disease, area leading cause of morbidity and mortality worldwide. Myocardial infarction (MI) results in extensive cardiomyocyte loss, inflammation, extracellular matrix (ECM) degradation, fibrosis, and ultimately, adverse ventricular remodeling associated with impaired heart function. While heart transplantation is the only definitive treatment for end-stage heart failure, donor organ scarcity necessitates the development of alternative therapies. In such cases, methods to promote endogenous tissue regeneration by stimulating growth factor secretion and vascular formation alone are insufficient. Techniques for the creation and transplantation of viable tissues are therefore highly sought after. Approaches to cardiac regeneration range from stem cell injections to epicardial patches and interposition grafts. While numerous preclinical trials have demonstrated the positive effects of tissue transplantation on vasculogenesis and functional recovery, long-term graft survival in large animal models is rare. Adequate vascularization is essential for the survival of transplanted tissues, yet pre-formed microvasculature often fails to achieve sufficient engraftment. Recent studies report success in enhancing cell survival rates in vitro via tissue perfusion. However, the transition of these techniques to in vivo models remains challenging, especially in large animals. This review aims to highlight the evolution of cardiac patch and stem cell therapies for the treatment of cardiovascular disease, identify discrepancies between in vitro and in vivo studies, and discuss critical factors for establishing effective myocardial tissue regeneration in vivo. Full article
(This article belongs to the Special Issue New Strategies for Cardiac Tissue Repair and Regeneration)
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28 pages, 2009 KiB  
Review
Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease
by Mark Broadwin, Frances Imarhia, Amy Oh, Christopher R. Stone, Frank W. Sellke, Sankha Bhowmick and M. Ruhul Abid
Bioengineering 2024, 11(3), 218; https://doi.org/10.3390/bioengineering11030218 - 25 Feb 2024
Cited by 4 | Viewed by 2497
Abstract
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart disease (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after revascularization is successfully implemented, there are a [...] Read more.
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart disease (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after revascularization is successfully implemented, there are a number of pathophysiological changes to the myocardium, including but not limited to ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion. Electrospinning, a nanofiber scaffold fabrication technique, has recently emerged as an attractive option as a potential therapeutic platform for the treatment of cardiovascular disease. Electrospun scaffolds made of biocompatible materials have the ability to mimic the native extracellular matrix and are compatible with drug delivery. These inherent properties, combined with ease of customization and a low cost of production, have made electrospun scaffolds an active area of research for the treatment of cardiovascular disease. In this review, we aim to discuss the current state of electrospinning from the fundamentals of scaffold creation to the current role of electrospun materials as both bioengineered extracellular matrices and drug delivery vehicles in the treatment of CVD, with a special emphasis on the potential clinical applications in myocardial ischemia. Full article
(This article belongs to the Special Issue New Strategies for Cardiac Tissue Repair and Regeneration)
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