Bioavailability and Health Benefits of Bioactive Compounds in Foods

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1681

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School of Nutrition, Health Sciences Division, Anahuac Mayab University, Km 15.5 Carretera Mérida a Progreso, Int. Km 2 Carretera a Chablekal, Mérida 97310, Yucatán, Mexico
Interests: food as bioactive substances; novel food ingredients; food authenticity; food sustainability
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Special Issue Information

Dear Colleagues,

Bioactive compounds, including polyphenols, carotenoids, vitamins, omega-3 fatty acids, organic acids, peptides, nucleosides and nucleotides, and phytosterols, have attracted great attention due to their role in the prevention of several chronic diseases. Bioactive compounds, naturally present in various foods, offer numerous health benefits, including antioxidant, anti-inflammatory, and anti-carcinogenic properties. However, their effectiveness largely depends on their bioavailability—the proportion of these compounds that can be absorbed and utilized by the body. This Special Issue compiles cutting-edge research and reviews that address the obtention and activity evaluation methods, factors influencing the bioavailability of bioactive compounds, innovative methods to enhance their absorption, and the subsequent health benefits that they provide. By exploring the intricate relationships between food composition, digestion, metabolism, and health outcomes, this Special Issue will bridge the gap between nutritional science and practical recommendations.

Dr. Jorge Carlos Ruíz-Ruíz
Guest Editor

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Keywords

  • bioavailability
  • metabolism
  • health benefits
  • bioactive compounds
  • foods

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Published Papers (2 papers)

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Research

18 pages, 8172 KiB  
Article
Amelioration of LPS-Induced Jejunum Injury and Mucus Barrier Damage in Mice by IgY Embedded in W/O/W Emulsion
by Zhaohui Wang, Ruihua Ye, Shidi Zhang, Chuanming Liu, Ke Chen, Kongdi Zhu, Pengjie Wang, Fuqing Wang and Jiaqiang Huang
Foods 2024, 13(24), 4138; https://doi.org/10.3390/foods13244138 - 20 Dec 2024
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Abstract
Chicken yolk immunoglobulin (IgY) is a natural immunologically active antibody extracted from egg yolk and can be used as a natural dietary supplement for the treatment of inflammation and damage to the intestines. In our study, IgY was embedded in a double emulsion [...] Read more.
Chicken yolk immunoglobulin (IgY) is a natural immunologically active antibody extracted from egg yolk and can be used as a natural dietary supplement for the treatment of inflammation and damage to the intestines. In our study, IgY was embedded in a double emulsion (W/O/W; DE) to explore the therapeutic effect of the embedded IgY on Lipopolysaccharide (LPS)-induced jejunal injury in mice. The results showed that W/O/W-embedded IgY as a dietary supplement (IgY + DE) attenuated LPS-induced damage to mouse small intestinal structures and protected the integrity of the jejunal mucosal barrier. IgY + DE increased the amount of related transcription factors (Math1, Spdef, Elf3, and Klf4) and promoted thrush cell differentiation. IgY + DE ameliorated LPS-induced reduction in mucin quantity and markers. It promoted the expression of Muc1 and Muc2 and increased the mRNA expression levels of Muc1, Muc2, Muc3, Muc4, Muc13, and Agr2 (p < 0.05). IgY + DE increased the expression of several glycosyltransferases involved in mucin glycosylation. IgY + DE also neutralized the LPS attack on the expression of jejunal inflammatory factors IL-1β, IL-6, IL-4, and TNF-α. In conclusion, the IgY-embedded double emulsion can be used as a dietary supplement for immunotherapy to prevent LPS-induced jejunal injury in mice. Full article
(This article belongs to the Special Issue Bioavailability and Health Benefits of Bioactive Compounds in Foods)
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14 pages, 440 KiB  
Article
Effect of Integrated Extraction Techniques on the Technofunctional and Bioactive Properties of Brosimum alicastrum Swartz Proteins
by María Fernanda Suárez-Hernández, Sara Gabriela Posada Ramirez, Darling del Carmen Castillo Cruz, Inocencio Higuera Ciapara, Neith Aracely Pacheco López, Iván Emanuel Herrera Pool and Jorge Carlos Ruiz-Ruiz
Foods 2024, 13(18), 2875; https://doi.org/10.3390/foods13182875 - 11 Sep 2024
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Abstract
This study addresses the need for effective protein extraction and characterization to unlock the potential of underutilized plant resources like Brosimum alicastrum Swartz nuts, aiming to enhance their value as functional ingredients in food applications. Extraction methods, including pH modulation, ultrasound-assisted extraction, and [...] Read more.
This study addresses the need for effective protein extraction and characterization to unlock the potential of underutilized plant resources like Brosimum alicastrum Swartz nuts, aiming to enhance their value as functional ingredients in food applications. Extraction methods, including pH modulation, ultrasound-assisted extraction, and enzymatic hydrolysis, are employed to enhance technofunctional and bioactive properties. The protein extracts are evaluated for solubility, emulsifying capacity, foaming properties, and water/oil-holding capacities to assess their technofunctional potential. Additionally, the bioactive properties, such as antioxidant and anti-inflammatory activities, are analyzed to explore potential health benefits. The results demonstrate that integrated extraction techniques significantly improve the yield and quality of Brosimum alicastrum Swartz nut proteins. Enzymatic hydrolysis, in particular, produces hydrolysates with superior bioactive properties. These findings highlight the potential of Brosimum alicastrum Swartz proteins as valuable ingredients for the food and pharmaceutical industries, promoting the utilization of underexploited plant resources for sustainable and health-promoting applications. Full article
(This article belongs to the Special Issue Bioavailability and Health Benefits of Bioactive Compounds in Foods)
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