Extended Data Figure 2: The distribution of KRAS hotspot mutations across tumour types. | Nature

Extended Data Figure 2: The distribution of KRAS hotspot mutations across tumour types.

From: Mutational landscape and significance across 12 major cancer types

Extended Data Figure 2

Distribution of changes caused by mutations of the KRAS hotspot at amino acids 12 and 13. Lung adenocarcinoma has a significantly higher proportion of Gly12Cys mutations than other cancers (P < 3.2 × 10−10), caused by the increase in C>A transversions in the genomic DNA at that location.

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