Supplementary Figure 10: Permutation test of overlap between approved drug _target–indications and genetic evidence (GWASdb or OMIM).
From: The support of human genetic evidence for approved drug indications
(a) The permutation scheme to simulate the null distribution. (b) The distribution of the percent of gene-trait and _target-indication pairs that overlap over 10,000 permutations and the overlap observed in the original data (red downward arrow). (c) The overlap observed in the original data overall and by disease category (red points) and the median percent overlap over 10,000 permutations (red ×).
