Abstract
An urgent need for societal transformation exists to reduce the environmental impact of humanity, because environmental health affects human health. Health care causes ~5% of global greenhouse gas emissions and other substantial and ongoing environmental harms. Thus, health-care professionals and managers must lead ongoing efforts to improve the environmental performance of health systems. Life-cycle assessment (LCA) is a methodology that enables estimation of environmental impacts of products and processes. It models environmental effects from ‘cradle’ (raw material extraction) to ‘grave’ (end of useful life) and conventionally reports a range of different impact categories. LCA is a valuable tool when used appropriately. Maximizing its utility requires rational assumptions alongside careful consideration of system boundaries and data sources. Well-executed LCAs are detailed and transparently reported, enabling findings to be adapted or generalized to different settings. Attention should be given to modelling mitigation solutions in LCAs. This important step can guide health-care systems towards new and innovative solutions that embed progress towards international climate agreements. Many urological conditions are common, recurrent or chronic, requiring resource-intensive management with large associated environmental impacts. LCAs in urology have predominantly focussed on greenhouse gas emissions and have enabled identification of modifiable ‘hotspots’ including electricity use, travel, single-use items, irrigation, reprocessing and waste incineration. However, the methodological and reporting quality of published urology LCAs generally requires improvement and standardization. Health-care evaluation and commissioning frameworks that value LCA findings alongside clinical outcomes and cost could accelerate sustainable innovations. Rapid implementation strategies for known environmentally sustainable solutions are also needed.
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References
IPCC. Climate Change 2023: Synthesis Report. Contribution of Working Groups I, II and III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC, 2023).
Kenny, C. & Priyadarshini, A. Review of current healthcare waste management methods and their effect on global health. Healthcare 9, 284 (2021).
Tennison, I. et al. Health care’s response to climate change: a carbon footprint assessment of the NHS in England. Lancet Planet. Health 5, e84–e92 (2021).
Lenzen, M. et al. The environmental footprint of health care: a global assessment. Lancet Planet. Health 4, e271–e279 (2020).
Romanello, M. et al. The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms. Lancet 402, 2346–2394 (2023).
Rockström, J. et al. A safe operating space for humanity. Nature 461, 472–475 (2009).
Drew, J., Christie, S. D., Rainham, D. & Rizan, C. HealthcareLCA: an open-access living database of health-care environmental impact assessments. Lancet Planet. Health 6, e1000–e1012 (2022).
Shackley, D. C. et al. Variation in the prevalence of urinary catheters: a profile of National Health Service patients in England. BMJ Open 7, e013842 (2017).
Rassweiler, J. J. et al. Future of robotic surgery in urology. BJU Int. 120, 822–841 (2017).
Checcucci, E. et al. New ultra-minimally invasive surgical treatment for benign prostatic hyperplasia: a systematic review and analysis of comparative outcomes. Eur. Urol. Open Sci. 33, 28–41 (2021).
Lang, J., Narendrula, A., El-Zawahry, A., Sindhwani, P. & Ekwenna, O. Global trends in incidence and burden of urolithiasis from 1990 to 2019: an analysis of Global Burden of Disease study data. Eur. Urol. Open. Sci. 35, 37–46 (2022).
Ferraro, P. M., Curhan, G. C., D’Addessi, A. & Gambaro, G. Risk of recurrence of idiopathic calcium kidney stones: analysis of data from the literature. J. Nephrol. 30, 227–233 (2017).
Strohmaier, W. L. Course of calcium stone disease without treatment. What can we expect? Eur. Urol. 37, 339–344 (2000).
Geraghty, R. M. et al. Best practice in interventional management of urolithiasis: an update from the European Association of Urology guidelines panel for urolithiasis 2022. Eur. Urol. Focus 9, 199–208 (2023).
MacNeill, A. J., Lillywhite, R. & Brown, C. J. The impact of surgery on global climate: a carbon footprinting study of operating theatres in three health systems. Lancet Planet. Health 1, e360–e367 (2017).
Rawla, P. Epidemiology of prostate cancer. World J. Oncol. 10, 63–89 (2019).
Babjuk, M. et al. European Association of Urology guidelines on non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ). Eur. Urol. 81, 75–94 (2022).
Alfred Witjes, J. et al. European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2023 guidelines. Eur. Urol. 85, 17–31 (2024).
Mottet, N. et al. EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer-2020 update. Part 1: screening, diagnosis, and local treatment with curative intent. Eur. Urol. 79, 243–262 (2021).
Ljungberg, B. et al. European Association of Urology guidelines on renal cell carcinoma: the 2022 update. Eur. Urol. 82, 399–410 (2022).
Kamat, A. M. et al. Bladder cancer. Lancet 388, 2796–2810 (2016).
Di Paolo, L., Abbate, S., Celani, E., Di Battista, D. & Candeloro G. Carbon footprint of single-use plastic items and their substitution. Sustainability 14, 16563 (2022).
Sun, A. J., Comiter, C. V. & Elliott, C. S. The cost of a catheter: an environmental perspective on single use clean intermittent catheterization. Neurourol. Urodyn. 37, 2204–2208 (2018).
Zhao, C. C., Comiter, C. V. & Elliott, C. S. Perspectives on technology: single-use catheters — evidence and environmental impact. BJU Int. 133, 638–645 (2024).
Brighton & Sussex Medical School, Centre for Sustainable Healthcare & UK Health Alliance on Climate Change. Green surgery: reducing the environmental impact of surgical care (UKHACC, 2023).
Stothers, L. & Macnab, A. Global implementation of advanced urological care: policy implementation research. Can. Urol. Assoc. J. 11, 157–160 (2017).
Toolan, M. et al. Environmental impact assessment in health technology assessment: principles, approaches, and challenges. Int. J. Technol. Assess. Health Care 39, e13 (2023).
Seifert, C., Koep, L., Wolf, P. & Guenther, E. Life cycle assessment as decision support tool for environmental management in hospitals: a literature review. Health Care Manag. Rev. 46, 12–24 (2021).
Hendrickson C. T. et al. Comparing two life cycle assessment approaches. In Proceedings of the 1997 IEEE International Symposium on Electronics and the Environment (IEEE, 1997).
Pan, X. & Kraines, S. Environmental input-output models for life-cycle analysis. Env. Resour. Econ. 20, 61–72 (2001).
Schaubroeck, T., Schrijvers, D., Schaubroeck, S. & Moretti, C. Definition of product system and solving multifunctionality in ISO 14040–14044: inconsistencies and proposed amendments — toward a more open and general LCA framework. Front. Sustain. 3, 778100 (2022).
Yang, Y., Heijungs, R. & Brandão, M. Hybrid life cycle assessment (LCA) does not necessarily yield more accurate results than process-based LCA. J. Clean. Prod. 150, 237–242 (2017).
Staffell, I. Measuring the progress and impacts of decarbonising British electricity. Energy Policy 102, 463–475 (2017).
Hauschild, M. Z. et al. Identifying best existing practice for characterization modeling in life cycle impact assessment. Int. J. Life Cycle Assess. 18, 683–697 (2013).
Cain, M. et al. Methane and the Paris Agreement temperature goals. Philos. Trans. R. Soc. A 380, 20200456 (2022).
International Organization for Standardization. ISO 14040:2006. Environmental Management — Life Cycle Assessment — Principles and Framework (International Organization for Standardization, 2006).
International Organization for Standardization. ISO 14044:2006. Environmental Management — Life Cycle Assessment — Requirements and Guidelines (International Organization for Standardization, 2006).
European Commission. International Reference Life Cycle Data System (ILCD) Handbook — General guide for Life Cycle Assessment — Provisions and Action Steps (JRC Publications Repository, 2010).
BP X30-323-0. General priniciples for an environmental communication on mass market products: part 0: general principles and methodological framework. Association Française de Normalisation https://www.boutique.afnor.org/en-gb/standard/bp-x303230/general-principles-for-an-environmental-communication-on-mass-market-produc/fa059632/45364 (2015).
International Organization for Standardization. ISO 14067:2018. Greenhouse gases — Carbon Footprint of Products — Requirements and Guidelines for Quantification (International Organization for Standardization, 2018).
BSI. PAS 2050:2011 (British Standards Institution, 2011).
World Resources Institute. Greenhouse Gas Protocol. Product Life Cycle Accounting and Reporting Standard (World Resources Institute, 2011).
Allison, C., Collins, M., Fisher, K. & Penny T. Greenhouse gas accounting sector guidance for pharmaceutical products and medical devices (Environmental Resources Management, 2012).
Pålsson, A.-C. & Riise, E. Defining the goal and scope of the LCA study. Tosca https://tosca-life.info/getting-started-guides/life-cycle-assessment/how-to-perform-an-lca/phases-in-an-lca-study/goal-and-scope/ (2011).
Pålsson, A.-C. & Riise, E. Performing the inventory in the LCA study. Tosca https://tosca-life.info/getting-started-guides/life-cycle-assessment/how-to-perform-an-lca/phases-in-an-lca-study/inventory/ (2011).
McGeoch, L., Hardie, T., Coxon, C. & Cameron G. Net Zero Care: What Will It Take? (The Health Foundation, 2023).
Barratt, A. L., Bell, K. J. L., Charlesworth, K. & McGain, F. High value health care is low carbon health care. Med. J. Aust. 216, 67–68 (2022).
Morgan, D. J., Dhruva, S. S., Coon, E. R., Wright, S. M. & Korenstein, D. Update on medical overuse. JAMA Intern. Med. 178, 110–115 (2018).
Brownlee, S. et al. Evidence for overuse of medical services around the world. Lancet 390, 156–168 (2017).
Zhi, M., Ding, E. L., Theisen-Toupal, J., Whelan, J. & Arnaout, R. The landscape of inappropriate laboratory testing: a 15-year meta-analysis. PLoS ONE 8, e78962 (2013).
John, J. B., Gray, W. K., O’Flynn, K., Briggs T. W. R. & McGrath J. S. The Getting It right First Time (GIRFT) programme in urology; rationale and methodology. BJU Int. 134, 141–147 (2024).
Syed, S. T., Gerber, B. S. & Sharp, L. K. Traveling towards disease. J. Community Health 38, 976–993 (2013).
Getting It Right First Time. Clinically-led specialty outpatient guidance. Practical OPD guidance for 17 services to maximise efficiency and reduce waiting times for patients (NHS England, 2023).
Get it Right First Time, British Association of Day Surgery & Centre for Perioperative Care. National day surgery delivery pack. GIRFT, BADS & CPOC https://cpoc.org.uk/national-day-surgery-pathway-delivery-pack-published-0 (2020).
Harrison, S. Urology: GIRFT Programme National Specialty Report (GIRFT, 2018).
Snowden, C. & Swart, M. Anaesthesia and Perioperative Medicine. GIRFT Programme National Specialty Report (GIRF, 2021).
Rayman, G. & Kar, P. Diabetes. GIRFT Programme National Specialty Report (GIRFT, 2020).
GIRFT. Getting it Right First Time. Frequently Asked Questions. GIRFT https://gettingitrightfirsttime.co.uk/wp-content/uploads/2017/12/Frequently-Asked-Questions-FINAL.pdf (2017).
van Hove, M. et al. Unwarranted variation and the goal of net zero for the NHS in England: exploring the link between efficiency working, patient outcomes and carbon footprint. Anaesthesia 79, 284–292 (2024).
Leapman, M. S. et al. Environmental impact of prostate magnetic resonance imaging and transrectal ultrasound guided prostate biopsy. Eur. Urol. 83, 463–471 (2023).
Asif, A. et al. Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non-inferiority within-patient, diagnostic yield trial protocol. BMJ Open 13, e0702080 (2023).
Mcalister, S. et al. The carbon footprint of hospital diagnostic imaging in Australia. Lancet Reg. Health West. Pac. 24, 100459 (2022).
Eldred-Evans, D. et al. An evaluation of screening pathways using a combination of magnetic resonance imaging and prostate-specific antigen: results from the IP1-PROSTAGRAM Study. Eur. Urol. Oncol. 6, 295–302 (2023).
Moore, C. M. et al. Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study. BMJ Oncol. 2, e000057 (2023).
Ilic, D. et al. Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer. Cochrane Database Syst. Rev. 9, CD009625 (2017).
Fuschi, A. et al. The impact of radical prostatectomy on global climate: a prospective multicentre study comparing laparoscopic versus robotic surgery. Prostate Cancer Prostatic Dis. 27, 272–278 (2023).
Rizan, C. et al. The carbon footprint of surgical operations: a systematic review. Ann. Surg. 272, 986–995 (2020).
Gani, A., Asjad, M., Talib, F., Khan, Z. A. & Siddiquee, A. N. Identification, ranking and prioritisation of vital environmental sustainability indicators in manufacturing sector using Pareto analysis cum best-worst method. Int. J. Sustain. Eng. 14, 226–244 (2021).
Chuter, R. et al. Towards estimating the carbon footprint of external beam radiotherapy. Phys. Med. 112, 102652 (2023).
NOAA. Sulphur hexafluoride. NOAA https://gml.noaa.gov/hats/combined/SF6.html (2024).
Choudhury, A. et al. Hypofractionated radiotherapy in locally advanced bladder cancer: an individual patient data meta-analysis of the BC2001 and BCON trials. Lancet Oncol. 22, 246–255 (2021).
Misrai, V. et al. A standardized method for estimating the carbon footprint of disposable minimally invasive surgical devices. Ann. Surg. 2, e094 (2021).
Leong, J. Y., Tokarski, A. T., Roehrborn, C. G. & Das, A. K. UroLift and Rezum: minimally invasive surgical therapies for the management of benign prostatic hyperplasia. Can. J. Urol. 28, 2–5 (2021).
Macneill, B. A. J. et al. Transforming the medical device industry: road map to a circular economy. Environ. Health 39, 2088–2097 (2020).
Davis, N. F. et al. Carbon footprint in flexible ureteroscopy: a comparative study on the environmental impact of reusable and single-use ureteroscopes. J. Endourol. 32, 214–217 (2018).
Baboudjian, M. et al. Life cycle assessment of reusable and disposable cystoscopes: a path to greener urological procedures. Eur. Urol. Focus 9, 681–687 (2023).
Kemble, J. P. et al. Environmental impact of single-use and reusable flexible cystoscopes. BJU Int. 131, 617–622 (2023).
Wombwell, A., Holmes, A. & Grills, R. Are single-use flexible cystoscopes environmentally sustainable? A lifecycle analysis. J. Clin. Urol. https://doi.org/10.1177/20514158231180661 (2023).
Hogan, D., Rauf, H., Kinnear, N. & Hennessey D. B. The carbon footprint of single-use flexible cystoscopes compared with reusable cystoscopes. J. Endourol. 36, 1460–1464 (2022).
Tauqeer, M. A. & Bang, K. E. Servitization: a model for the transformation of products into services through a utility-driven approach. J. Open. Innov. Technol. Mark. Complex. 4, 60 (2018).
Li, K., Wang, J., Feng, L. & Zhu, L. Re-discussion of servitization strategy and firm performance. Front. Psychol. 13, 1022648 (2022).
Rizan, C. & Bhutta, M. Re: the carbon footprint of single-use flexible cystoscopes compared with reusable cystoscopes: methodological flaws led to the erroneous conclusion that single-use ‘is better’. J. Endourol. 36, 1466–1467 (2022).
Simera, I. et al. Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network. BMC Med. 8, 24 (2010).
John, J. B. et al. The carbon footprint of the perioperative transurethral resection of bladder tumour pathway. BJU Int. https://doi.org/10.1111/bju.16477 (2024).
GIRFT. Urology: towards better care for patients with bladder cancer (GIRFT, 2022).
Association of the British Pharmaceutical Industry. ABPI Blister Pack Carbon Footprint Tool (ABPI, 2023).
Budzinski, K. et al. Introduction of a process mass intensity metric for biologics. N. Biotechnol. 49, 37–42 (2019).
Anastas, P. & Eghbali, N. Green chemistry: principles and practice. Chem. Soc. Rev. 39, 301–312 (2010).
Parvatker, A. G. et al. Cradle-to-gate greenhouse gas emissions for twenty anesthetic active pharmaceutical ingredients based on process scale-up and process design calculations. Sustain. Chem. Eng. 7, 6580–6591 (2019).
Budzinski, K. et al. Streamlined life cycle assessment of single use technologies in biopharmaceutical manufacture. N. Biotechnol. 68, 28–36 (2022).
Mcgain, F., Moore, G. & Black, J. Hospital steam sterilizer usage: could we switch off to save electricity and water? J. Health Serv. Res. Policy 21, 166–171 (2016).
McGain, F., Moore, G. & Black, J. Steam sterilisation’s energy and water footprint. Aust. Heal. Rev. 41, 26–32 (2017).
Rizan, C., Lillywhite, R., Reed, M. & Bhutta, M. F. Minimising carbon and financial costs of steam sterilisation and packaging of reusable surgical instruments. Br. J. Surg. 109, 200–210 (2022).
AHSN. An Innovation Agency report for the NHSE Sustainable Procurement Team. Surgical instrument set rationalisation: understanding the benefits and replicating the process (Innovation Agency, 2023).
Boag, K. et al. Introducing green innovation into clinical practice. Bull. R. Coll. Surg. Engl. 104, 140–144 (2022).
Rizan, C., Bhutta, M. F., Reed, M. & Lillywhite, R. The carbon footprint of waste streams in a UK hospital. J. Clean. Prod. 286, 125446 (2021).
Thiel, C. L., Woods, N. C. & Bilec, M. M. Strategies to reduce greenhouse gas emissions from laparoscopic surgery. Am. J. Public Health 108, S158–S164 (2018).
Sustainable Development Unit. Public opinion survey 2015. Sustainability and the NHS, Public Heath and Social Care system — Ipsos Mori survey (NHS England, 2016).
Enventure Resarch. NHS Sustainable Development Unit Study Report (NHS England, 2017).
Phull, M. et al. Potential carbon savings with day-case compared to inpatient transurethral resection of bladder tumour surgery in England: a retrospective observational study using administrative data. Eur. Urol. Open Sci. 52, 44–50 (2023).
John, J. B. et al. Carbon footprint of hospital laundry: a life cycle assessment. BMJ Open 14, e080838 (2024).
Benedettini, O. Green servitization in the single-use medical device industry: how device OEMs create supply chain circularity through reprocessing. Sustainability 14, 12670 (2022).
Lepp, K., Vornanen, L. & Savinen, O. Lifecycle extension of single-use medical device sensors: case study of an engineering sustainability transition program. J. Clean Prod. 423, 138518 (2023).
Bhutta, M. F. Our over-reliance on single-use equipment in the operating theatre is misguided, irrational and harming our planet. Ann. R. Coll. Surg. Engl. 103, 709–712 (2021).
Powles, T. et al. Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 23, 1133–1144 (2022).
Gourd, E. Neoadjuvant pembrolizumab in bladder cancer. Lancet Oncol. 19, e669 (2018).
Cristobal-Garcia, J., Pant, P., Reale, F. & Sala, S. Life Cycle Assessment for the Impact Assessment of Policies (European Union, 2016).
Huijbregts, M. A. J. et al. ReCiPe2016: a harmonised life cycle impact assessment method at midpoint and endpoint level. Int. J. Life Cycle Assess. 22, 138–147 (2017).
Forster, P. et al. in Climate Change 2021: The Physical Science Basis Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (eds Masson-Delmotte, V. et al.) 923–1054 (Cambridge University Press, 2023).
Lindsey, R. Climate change: atmospheric carbon dioxide. NOAA https://www.climate.gov/news-features/understanding-climate/climate-change-atmospheric-carbon-dioxide (2024).
NASA. Carbon dioxide. NASA https://climate.nasa.gov/vital-signs/carbon-dioxide/?intent=121 (2024).
NASA. A global view of methane. NASA Earth Observatory https://earthobservatory.nasa.gov/images/87681/a-global-view-of-methane (2016).
Global Monitoring Laboratory. Trends in CO2, CH4, N2O, SF6. NOAA https://gml.noaa.gov/ccgg/trends/ (2024).
US Environmental Protection Agency. Climate change indicators: atmospheric concentrations of greenhouse gases. EPA https://www.epa.gov/climate-indicators/climate-change-indicators-atmospheric-concentrations-greenhouse-gases (2024).
Busenberg, E. & Plummer, N. Dating young groundwater with sulfur hexafluoride: natural and anthropogenic sources of sulfur hexafluoride. Water Resour. Res. 36, 3011–3030 (2000).
NOAA. HFC-32. NOAA https://gml.noaa.gov/hats/gases/HFC32.html (2024).
NOAA. HFC-134a. NOAA https://gml.noaa.gov/hats/gases/HFC134a.html (2024).
NOAA. CFC-11. NOAA https://gml.noaa.gov/hats/combined/CFC11.html (2024).
Meinshausen, M. et al. The RCP greenhouse gas concentrations and their extensions from 1765 to 2300. Clim. Change 109, 213–241 (2011).
NOAA. CF4 (Tetrafluoromethane). NOAA https://gml.noaa.gov/hats/gases/CF4.html (2024).
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Ecoinvent database (v3.10): https://support.ecoinvent.org/ecoinvent-version-3.10
EQUATOR network: https://www.equator-network.org/
GIRFT: https://gettingitrightfirsttime.co.uk/what-we-do/
GIRFT academy resources: https://gettingitrightfirsttime.co.uk/academy-resources/
GIRFT all clinical metrics: https://model.nhs.uk/home
Greener NHS areas of focus: https://www.england.nhs.uk/greenernhs/a-net-zero-nhs/areas-of-focus/
Greener NHS net zero supplier roadmap: https://www.england.nhs.uk/greenernhs/get-involved/suppliers/
Sustainable Healthcare Coalition core pathway carbon calculator: https://shcoalition.org/care-pathway-carbon-calculator-2/
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John, J.B., Gray, W.K., Briggs, T.W.R. et al. Measuring and improving the cradle-to-grave environmental performance of urological procedures. Nat Rev Urol (2024). https://doi.org/10.1038/s41585-024-00937-0
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DOI: https://doi.org/10.1038/s41585-024-00937-0