Rechtman et al. analyse the exposome of rescue and recovery workers who attended the World Trade Center on and after September 11, 2001. Mental and physical health outcomes associate with all aspects of occupational history, as well as traumatic and environmental exposures.

Stephenson, Pinto Pereira et al. investigate the proportion of children and young people with Post Covid-19 condition 24-months post-infection. Only 7.2% meet the definition consistently at 3-, 6-, 12- and 24-months post-infection, highlighting the importance of longitudinal studies.

Bellomo et al. highlight the importance of umbrella reviews and discuss their limitations and potential. They specifically evaluate the methods used in published umbrella reviews on vaccines, to illustrate the diversity of approaches currently adopted.

Huang et al. train and optimize a machine learning model using patient characteristics and NMR biomarkers to predict Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cases in the UK Biobank. This works explores the heterogenous symptoms and comorbidities of this condition.

Singh, Goerlich et al. transplant 10 gene modified pig hearts into non-human primates. Life-supporting function occurred for up to 225 days but there was evidence of adipose deposition, chronic vasculopathy, micro and macro thrombosis, and acute cellular rejection.

Lee et al. investigate whether the wastewater resistome of a large Canadian city associates with socioeconomic status (SES) of resident populations using a granular, neighborhood-based approach. No correlation is seen, in contrast with data from other cities around the world, where AMR genes disproportionately concentrate in cities with lower SES.

Schlesinger and Alam et al. utilize a deep neural network and single-lead electrocardiogram data to determine elevated left atrial pressure in patients. This work aims to identify patients at risk of pulmonary congestion and guide proactive heart failure care.

Cohen et al. report a patient-led case series of 13 individuals with Long COVID who initiated extended courses of Paxlovid outside of, or within the context of, an acute SARS-CoV-2 infection. Long courses of nirmatrelvir/ritonavir have meaningful benefits for some people with Long COVID but not all.

Suzuki, Kojima et al. develop a deep learning segmentation tool to quantify interstitial fibrosis and inflammatory cell infiltration in digital pathology biopsies of chronic kidney disease. They show algorithm’s concordance with estimated glomerular filtration rate and nephrologists’ evaluations in multiple cohorts.

Jeong, Ejima and Kim et al. assess the effectiveness of various screening strategies with antigen tests for COVID-19 infections in schools and workplaces. A computational framework is employed to determine the best strategies while considering factors such as within-host viral dynamics, transmissions, screening schedules and test sensitivity.

Anachebe et al. discuss how to center equity in medical school admissions by presenting an equity-based framework that focuses on recruiting, standards, selection and support. Their recommended strategies are universally applicable across training programs and are accompanied by a number of promising examples.

Kidenya and Mboowa discuss the current state of genomic inclusiveness in medicine. They champion the efforts of the All of Us Research Program to broaden diversity in population genomics and reduce disparities across different ancestries.

Gogishvili et al highlight the crucial role of digital health interventions (DHIs) in improving HIV care outcomes and experiences. They provide recommendations for the equitable integration of DHIs in the HIV care cascade, emphasizing the need to address the digital divide to ensure inclusive access to healthcare.

Kalungi et al. highlight the underrepresentation of African populations in psychiatric genetic research. They advocate for strategic investments, capacity building, and collaboration to empower African scientists and institutions, emphasizing community engagement and ethical considerations for robust and culturally sensitive research in Africa.

Asrar et al. discuss the steps that the space sector is taking towards promoting equity, diversity, inclusion and accessibility, such as the world’s first parastronaut program. They propose that healthcare can learn from the space sector in enhancing disability inclusion and support for people, including healthcare workers, with disabilities.

Chisholm-Burns et al. discuss the substantial shortage of organs available for transplantation, with disparities in access amongst some racial and ethnic groups. The authors suggest that while xenotransplantation can potentially increase organ availability, it also has the potential to further embed inequities in transplant care.