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Cells are the fundamental, structural, and functional units of living organisms. Cells are composed of cytoplasm containing various organelles, such as the nucleus, in which the DNA is stored, or mitochondria, which participate in energy production. Animal Cells are limited by their plasma membrane while plant and fungi cells have an additional cell wall.
The vascular system has many different functions across the human body beyond its role in oxygen and nutrient transport. We explored vascular cell heterogeneity by integrating single-cell RNA-sequencing data from the Human Cell Atlas and ongoing collaborations across 19 healthy human organs and tissues, and highlight shared and distinct molecular features of vascular beds.
Adipose tissue accommodates large volume changes upon expansion, but the molecular mechanisms involved are not fully understood. Here, Aboy et al. describe CAV1 Y14 phosphorylation as required for appropriate adipocyte caveolae flattening and homeostasis.
Cell fate canalization is a core biological event. The authors uncover the role of ARID1A at a super-enhancer region of osteoclast lineage master transcription factor, and antagonistic action between distinct BAF complexes in the proper cell fate canalization.
The vascular system has many different functions across the human body beyond its role in oxygen and nutrient transport. We explored vascular cell heterogeneity by integrating single-cell RNA-sequencing data from the Human Cell Atlas and ongoing collaborations across 19 healthy human organs and tissues, and highlight shared and distinct molecular features of vascular beds.
A study reports that adipocytes can regulate the metabolism of fibroblasts in the healthy synovium via cortisol, but in inflammatory arthritis adiposity is lost and fibroblasts become pathogenic.
New research suggests that insulin-like growth factor 1 is an important contributor to Wnt-induced joint damage, and that its suppression could represent a promising therapeutic strategy for osteoarthritis.
