Epigenomics articles from across Nature Portfolio

A rat study suggests that maternal stress induces epigenetic signatures in placenta and brain that persist across four generations of offspring, proposing that diseases may be inherited by experience-induced non-genetic mechanisms.

Nshanian et al. investigate the differential effects of the short-chain fatty acids propionate and butyrate on chromatin remodelling and gain insight into the mechanisms that drive selective histone acylation.

The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.

Long-read sequencing technologies have revolutionized genomics and transcriptomics, and more recently enabled comprehensive epigenomic profiling. These advances now also allow investigation of the relationship between chromatin states and transcriptional dynamics.

Perez, Goronzy et al. present ChIP-DIP, which enables multiplex genomic mapping of hundreds of epitopes from a single sample. The authors apply ChIP-DIP to localize modified histones, transcription factors and other chromatin-interacting proteins at scale, in both cell lines and primary cells.

In this Tools of the Trade article, Andrew Russell describes Slide-tags, a method for scalable, spatially resolved single-nucleus sequencing.

In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the genome and regulate gene expression.

Hemichordates hold a key position in the animal tree of life that makes them a useful organism for genetic studies that compare the evolutionary mechanisms behind different metazoan life strategies. Gene expression analysis in developing hemichordates suggests that the last common ancestor (LCA) of deuterostomes might be more similar to the LCA of bilaterians than previously thought.