Virus structures articles from across Nature Portfolio

The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.

Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus assembly and replication within these condensates.

African swine fever virus (ASFV) is a contagious DNA virus causing lethal disease in swine. This study reveals structures of ASFV RNA polymerase bound to protein M1249L, showing its vital roles in regulating early transcription and packaging.

The study reveals how a satellite phage-encoded protein directs the assembly of coat proteins into small capsids.

This study provides insights into how to determine how mimiviruses package and protect their genomes.

This study reveals that a cross-neutralizing antibody _targets a conserved site on betacoronavirus spike proteins and confers protection against SARS-CoV-2 infection.

Cell entry mechanisms of the non-enveloped viruses bluetongue and rhesus rotavirus are delineated using structural and molecular biology.

This study provides ultrastructural evidence that the HIV-1 capsid can enter the nucleus of an infected T cell line through the nuclear pore complex and fragments in the nucleoplasm to release the viral genome.