- ADL
activities of daily living
- ANCOVA
analysis of covariance
- APTC
Anti-Platelet Triallists’ Collaboration
- AUC
area under the curve
- AWI
average weighted impact
- BCVA
best corrected visual acuity
- BNF
British National Formulary
- BP
blood pressure
- CARF
Central Angiographic Resource Facility
- CEAC
cost-effectiveness acceptability curve
- CFP
colour fundus photography
- CI
confidence interval
- CLARITY
clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy
- CONSORT
Consolidated Standards of Reporting Trials
- CSRI
client service receipt inventory
- CST
central subfield thickness
- DD
disc diameter
- DMEC
Data Monitoring and Ethics Committee
- DMO
diabetic macular oedema
- eCRF
electronic case report form
- EDC
electronic data capture
- EMA
European Medicines Agency
- EQ-5D-3L
EuroQol-5 Dimensions, three-level version
- ETDRS
Early Treatment Diabetic Retinopathy Study
- EudraCT
European Union Drug Regulating Authorities Clinical Trials
- FA
fluorescein angiography
- FDA
US Food and Drug Administration
- FFA
fundus fluorescein angiography
- HbA1c
glycated haemoglobin
- HRQoL
health-related quality of life
- ICECAP-A
Investigating Choice Experiments Capability Measure for Adults
- ICER
incremental cost-effectiveness ratio
- ICH
International Conference on Harmonisation
- IMP
investigational medicinal product
- IQR
interquartile range
- ITT
intention to treat
- KCTU
King’s Clinical Trials Unit
- LME
linear mixed-effects
- MAR
missing at random
- MHRA
Medicines and Healthcare products Regulatory Agency
- mRNA
messenger ribonucleic acid
- NEI-VFQ-25
National Eye Institute Visual Function Questionnaire
- NetwORC UK
Network of Ophthalmic Reading Centres UK
- NICE
National Institute for Health and Care Excellence
- NIHR
National Institute for Health Research
- NV
neovascularisation
- NVA
neovascularisation of the angle
- NVG
neovascular glaucoma
- NVI
neovascularisation of iris
- OBE
Officer of the Most Excellent Order of the British Empire
- OCT
optical coherence tomography
- PAS
Patient Access Scheme
- PDR
proliferative diabetic retinopathy
- PIN
patient identification number
- PP
per protocol
- PRP
panretinal photocoagulation
- QALY
quality-adjusted life-year
- RCT
randomised controlled trial
- RetDQoL
Retinopathy-Dependent Quality-of-Life Questionnaire
- RetTSQ
Retinopathy Treatment Satisfaction Questionnaire
- SAE
serious adverse event
- SD
standard deviation
- SD-OCT
spectral-domain optical coherence tomography
- SE
standard error
- SOP
standard operating procedure
- TMG
Trial Management Group
- TSC
Trial Steering Committee
- VEGF
vascular endothelial growth factor
