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Review
. 2001 Jun;2(6):773-7.

The CD40-CD40 ligand system: a potential therapeutic _target in atherosclerosis

R P Phipps  1 , L Koumas, E Leung, S Y Reddy, T Blieden, J Kaufman
Affiliations
  • PMID: 11572655
Review

The CD40-CD40 ligand system: a potential therapeutic _target in atherosclerosis

R P Phipps et al. Curr Opin Investig Drugs. 2001 Jun.

Abstract

Atherosclerosis is a leading cause of cardiovascular disease in the westernized world. This review highlights emerging evidence linking atherosclerosis to the CD40-CD40 ligand (CD154) pathway. Recently, atherosclerosis has been associated with chronic inflammation, linking it to the immune system. This novel viewpoint may serve as an additional _target for therapeutic intervention. CD40 and CD154 are highly expressed in atherosclerotic human plaques. Recent data from preclinical animal models of atherosclerosis show that disruption of the CD40-CD154 pathway can prevent atherosclerotic progression and may reverse established lesions. Blockade of the CD40-CD154 pathway by biologicals or small molecules may prove valuable in the treatment of atherosclerosis.

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