Interleukin-6 is a direct mediator of T cell migration
- PMID: 15368306
- DOI: 10.1002/eji.200425237
Interleukin-6 is a direct mediator of T cell migration
Abstract
Interleukin (IL)-6 is a pleiotropic cytokine involved in the differentiation and proliferation of hematopoietic cells. Hepatocytes respond to IL-6 with the synthesis and secretion of acute-phase proteins. In addition, IL-6 plays a role as a migration factor in vivo. In the present paper, we studied the potential of IL-6 to mediate migration of human primary T cells and T cell-derived cell lines. IL-6 was found to induce migration only in the presence of extracellular matrix, suggesting a cross-talk between the IL-6- and integrin signal transduction pathways. Furthermore, an IL-6 gradient is required for chemotactic migration. This activity is not due to the release of secondary chemotactic activities, but is a direct response to IL-6. T cell migration could also be observed in response to IL-11, but no migration was found after stimulation with leukemia inhibitory factor or oncostatin M, although these cytokines signal through gp130-containing receptor complexes. Finally, we present evidence that activation of the mitogen-activated protein kinase (MAPK) cascade, the phosphatidylinositol 3-kinase as well as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is crucial for IL-6-induced migration. Selective activation of the JAK/STAT or the MAPK cascade by mutated receptor proteins shows a crucial role of IL-6-initiated SH2 domain-containing tyrosine phosphatase 2/MAPK activity for migration.
Similar articles
-
Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation.Biochem J. 2008 May 15;412(1):65-72. doi: 10.1042/BJ20071572. Biochem J. 2008. PMID: 18271757
-
Interleukin-6 and oncostatin M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.Prostate. 2005 Jul 1;64(2):209-16. doi: 10.1002/pros.20235. Prostate. 2005. PMID: 15712220
-
Role of mitogen-activated protein kinases in Thy-1-induced T-lymphocyte activation.Cell Signal. 2009 Aug;21(8):1298-307. doi: 10.1016/j.cellsig.2009.03.014. Epub 2009 Mar 24. Cell Signal. 2009. PMID: 19324083
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation.Biochem J. 2003 Aug 15;374(Pt 1):1-20. doi: 10.1042/BJ20030407. Biochem J. 2003. PMID: 12773095 Free PMC article. Review.
-
Interleukin-6 and interleukin-11: same same but different.Biol Chem. 2013 Sep;394(9):1145-61. doi: 10.1515/hsz-2013-0166. Biol Chem. 2013. PMID: 23740659 Review.
Cited by
-
Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis.Biomol Ther (Seoul). 2010 Apr;18(2):135-144. doi: 10.4062/biomolther.2010.18.2.135. Biomol Ther (Seoul). 2010. PMID: 21072258 Free PMC article.
-
Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs.Commun Biol. 2022 Jan 13;5(1):52. doi: 10.1038/s42003-021-02977-3. Commun Biol. 2022. PMID: 35027657 Free PMC article.
-
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.J Immunol. 2015 Jul 15;195(2):695-705. doi: 10.4049/jimmunol.1403187. Epub 2015 Jun 1. J Immunol. 2015. PMID: 26034173 Free PMC article.
-
Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection.Am J Transplant. 2009 Aug;9(8):1773-83. doi: 10.1111/j.1600-6143.2009.02706.x. Epub 2009 Jun 16. Am J Transplant. 2009. PMID: 19538487 Free PMC article.
-
Sympathetic nerve-adipocyte interactions in response to acute stress.J Mol Med (Berl). 2022 Feb;100(2):151-165. doi: 10.1007/s00109-021-02157-0. Epub 2021 Nov 4. J Mol Med (Berl). 2022. PMID: 34735579 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
