Canonical and non-canonical autophagy: variations on a common theme of self-eating?

doi:10.1038/nrm3249

Review

. 2011 Dec 14;13(1):7-12.

doi: 10.1038/nrm3249.

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Patrice Codogno¹, Maryam Mehrpour, Tassula Proikas-Cezanne

Affiliations

PMID: 22166994
DOI: 10.1038/nrm3249

Review

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Patrice Codogno et al. Nat Rev Mol Cell Biol. 2011.

. 2011 Dec 14;13(1):7-12.

doi: 10.1038/nrm3249.

Authors

Patrice Codogno¹, Maryam Mehrpour, Tassula Proikas-Cezanne

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale (INSERM), University Paris-Sud 11, Châtenay-Malabry, France.

PMID: 22166994
DOI: 10.1038/nrm3249

Abstract

The autophagosome is the central organelle in macroautophagy, a vacuolar lysosomal catabolic pathway that degrades cytoplasmic material to fuel starving cells and eliminates intracellular pathogens. Macroautophagy has important physiological roles during development, ageing and the immune response, and its cytoprotective function is compromised in various diseases. A set of autophagy-related (ATG) proteins is hierarchically recruited to the phagophore, the initial membrane template in the construction of the autophagosome. However, recent findings suggest that macroautophagy can also occur in the absence of some of these key autophagy proteins, through the unconventional biogenesis of canonical autophagosomes. Such alternatives to the evolutionarily conserved scheme might provide additional therapeutic opportunities.

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References

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[1] Mol Cell. 2009 Feb 27;33(4):505-16 - PubMed

[2] Mol Cell. 2009 Feb 27;33(4):505-16 - PubMed

[3] Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14 - PubMed

[4] Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14 - PubMed

[5] Nature. 2010 Jul 1;466(7302):68-76 - PubMed

[6] Nature. 2010 Jul 1;466(7302):68-76 - PubMed

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[9] Nat Cell Biol. 2010 Sep;12(9):814-22 - PubMed

[10] Nat Cell Biol. 2010 Sep;12(9):814-22 - PubMed

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Canonical and non-canonical autophagy: variations on a common theme of self-eating?

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Canonical and non-canonical autophagy: variations on a common theme of self-eating?

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Abstract

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