Host Genetics and Gut Microbiome: Challenges and Perspectives

doi:10.1016/j.it.2017.06.003

Review

. 2017 Sep;38(9):633-647.

doi: 10.1016/j.it.2017.06.003. Epub 2017 Jun 29.

Host Genetics and Gut Microbiome: Challenges and Perspectives

Alexander Kurilshikov¹, Cisca Wijmenga², Jingyuan Fu³, Alexandra Zhernakova⁴

Affiliations

¹ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
² University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands; K.G. Jebsen Coeliac Disease Research Centre, Department of Immunology, University of Oslo, Oslo, Norway.
³ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands.
⁴ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands. Electronic address: a.zhernakova@umcg.nl.

PMID: 28669638
DOI: 10.1016/j.it.2017.06.003

Review

Host Genetics and Gut Microbiome: Challenges and Perspectives

Alexander Kurilshikov et al. Trends Immunol. 2017 Sep.

. 2017 Sep;38(9):633-647.

doi: 10.1016/j.it.2017.06.003. Epub 2017 Jun 29.

Authors

Alexander Kurilshikov¹, Cisca Wijmenga², Jingyuan Fu³, Alexandra Zhernakova⁴

Affiliations

¹ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
² University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands; K.G. Jebsen Coeliac Disease Research Centre, Department of Immunology, University of Oslo, Oslo, Norway.
³ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands.
⁴ University of Groningen, University Medical Center Groningen, Department of Genetics, P.O. Box 30001, 9700 RB Groningen, The Netherlands. Electronic address: a.zhernakova@umcg.nl.

PMID: 28669638
DOI: 10.1016/j.it.2017.06.003

Abstract

The mammalian gut is colonized by trillions of microorganisms collectively called the microbiome. It is increasingly clear that this microbiome has a critical role of in many aspects of health including metabolism and immunity. While environmental factors such as diet and medications have been shown to influence the microbiome composition, the role of host genetics has only recently emerged in human studies and animal models. In this review, we summarize the current state of microbiome research with an emphasis on the effect of host genetics on the gut microbiome composition. We focus particularly on genetic determinants of the host immune system that help shape the gut microbiome and discuss avenues for future research.

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Host Genetics and Gut Microbiome: Challenges and Perspectives

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Host Genetics and Gut Microbiome: Challenges and Perspectives

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