Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2019 Apr 18;14(4):e0215222.
doi: 10.1371/journal.pone.0215222. eCollection 2019.

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

Rafael Gutiérrez Campos  1 , Angélica Malacara Rosas  1 , Elvia Gutiérrez Santillán  2 , Mireya Delgado Gutiérrez  3 , Rusland Enrique Torres Orozco  1 , Elí Daniel García Martínez  1 , Luis Fernando Torres Bernal  4 , Alejandro Rosas Cabral  4
Affiliations
Clinical Trial

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

Rafael Gutiérrez Campos et al. PLoS One. .

Abstract

Human papillomavirus has been identified as a main etiological agent in the development of cervical cancer. HPV 16 and 18 have been reported the most widely prevalent genotypes worldwide. We conducted a study analyzing the prevalence of high and low risk human papillomavirus viral types in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in central Mexico. Specific viral genotype was determined by a PCR and hybridization-based detection test. The presence of 37 high- and low-risk HPV genotypes was evaluated in 883 female participants. Of these, 350 presented low-grade squamous intraepithelial lesions (LGSIL), 176 presented high-grade squamous intraepithelial lesions (HGSIL), 107 suffered from cervical cancer and 250 women with negative cytological report for intraepithelial lesion or malignancy (NILM). HPV 51 was the most prevalent genotype, followed by HPV 16: overall prevalence of HPV 51, including single infections and co-infections was 31.2% in women with LGSIL, whereas prevalence of HPV 16 was 25.1%. Among women with HGSIL, HPV 51 prevalence was 47.2% and HPV 16 was 30.1%. Prevalence of HPV 51 in women with cervical cancer was 49.5% and type 16 was 33.6%. Between single and co-infections, most co-infections were not associated with later stages of the disease, except 51/16 and some others. HPV 51 showed a significant correlation with the progression of the disease (OR = 10.81 for LGSIL, 19.38 for HGSIL and 22.95 for ICC), and when analyzing all other genotypes, five different groups depending on their correlation with all lesion grades were determined. According to our findings, HPV genotype 51 has a higher prevalence than HPV 16 and 18 in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in Central Mexico.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lizano M, Berumen J, García-Carrancá A. HPV-related Carcinogenesis: Basic Concepts, Viral Types and Variants. Archives of Medical Research. 2009;40(6):428–34. 10.1016/j.arcmed.2009.06.001 - DOI - PubMed
    1. Arrossi S, Sankaranarayanan R, Parkin DM. Incidence and mortality of cervical cancer in Latin America. Salud Publica Mex. 2003;45 Suppl 3:S306–14. - PubMed
    1. Denny L, Adewole I, Anorlu R, Dreyer G, Moodley M, Smith T, Snyman L, Wiredu E, Molijn A, Quint W, Ramakrishnan G, Schmidt J. Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa. Int J Cancer. 2014;134(6):1389–98. 10.1002/ijc.28425 - DOI - PubMed
    1. Bhaumik S. India has world’s highest number of cervical cancer deaths. BMJ. 2013;346:f3108 10.1136/bmj.f3108 - DOI - PubMed
    1. Bosch X, Sanjose S. Chapter 1: Human papillomavirus and cervical cancer—burden and assessment of causality. J Nat Cancer Inst Monogr. 2003;31:3–13. - PubMed

Publication types

Grants and funding

The research was partially funded by grants: FOMIX- CONACYT- Estado de Aguascalientes (09-131282) and Autonomous University of Aguascalientes (PIBB10N-07).
  NODES
Association 2
twitter 2