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Randomized Controlled Trial
. 2024 Nov 21;16(23):3990.
doi: 10.3390/nu16233990.

Weizmannia coagulans BC99 Improves Strength Performance by Enhancing Protein Digestion and Regulating Skeletal Muscle Quality in College Students of Physical Education Major

Li Cao  1   2 , Minghan Guo  1 , Yiqing Zhou  1 , Jie Zhang  1 , Shanshan Tie  1 , Xuan Li  1   3 , Pingping Tian  1   2 , Ying Wu  1 , Shaobin Gu  1   2   3
Affiliations
Randomized Controlled Trial

Weizmannia coagulans BC99 Improves Strength Performance by Enhancing Protein Digestion and Regulating Skeletal Muscle Quality in College Students of Physical Education Major

Li Cao et al. Nutrients. .

Abstract

Background: The dietary proteins are one of the most important factors determining health conditions in humans. The sufficient digestion and absorption of dietary proteins in the digestive tract has positive effects on performance and recovery in sportspeople and athletes. Improving protein digestibility is a strategy for maintaining health status and optimal performance in sport and exercise activities. Objectives: The aim of the present study is to verify whether Weizmannia coagulans BC 99 (BC99) can increase muscle mass and strength. Methods: This randomized double-blind, controlled trial assigned 72 male college students to receive probiotics (n = 36, 20.25 ± 1.03 years; 179.00 ± 5.94 cm; 73.55 ± 8.73 kg, protein powder with BC99) or the placebo (n = 36, 20.19 ± 0.79 years; 179.25 ± 5.16 cm; 73.61 ± 8.24 kg, protein powder) for 12 weeks. At the baseline and final stages of the study, strength tests and body composition assessment were performed. Blood and stool samples were taken at the end of the 12-week intervention, and digestive enzymatic activity of stool samples, biochemical parameters, amino acids and hormone level of plasma were analyzed. Results: BC99 administration significantly improved strength performance, skeletal muscle mass, activity of pepsin and trypsin, the concentrations of branched chain amino acids and essential amino acids, reduced activities of creatine kinase and lactic dehydrogenase and urea nitrogen (BUN) level and increased testosterone and glucagon-like peptide-1 level in male college students. Conclusions: Therefore, BC99 supplementation can be an important nutritional strategy to improve strength performance, body composition, protein digestion and body metabolism in healthy young males.

Keywords: inflammation; oxidative stress; probiotic; protein digestion; skeletal muscle; strength performance.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The schedule of procedure for the present study.
Figure 2
Figure 2
Changes in enzymatic activity of stool samples. (A): Changes in pepsin activity. (B): Changes in trypsin activity. (C): Changes in lipase activity. Data are expressed as mean ± SD. ** means the difference is significant at the 0.01 level.
Figure 3
Figure 3
Changes in plasma hormone level. (A): Changes in plasma testosterone level. (B): Changes in t glucagon-like peptide-1 level. Data are expressed as mean ± SD. * means the difference is significant at the 0.01 level.
See this image and copyright information in PMC

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