Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
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Tel 984-287-3108
Fax 919-541-3647
[email protected]
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530 Davis Drive (Keystone Bldg)
Research Summary
The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch and across the National Toxicology Program.
Specific projects include:
- Development of toxicogenomic models that predict apical toxicological outcomes
- Evaluation of methods for scaling toxicogenomic technologies
- In vitro / In vivo extrapolation
- Analytics pipeline development for Tox21 high throughput screening data
- Development of network-based inference approaches for biological read-across using Tox21 data
- Development of software for genomic benchmark dose analysis
Scientists & Staff
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
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Tel 984-287-3108
Fax 919-541-3647
[email protected]
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Frank G. Chao, Ph.D.
Computational Biologist
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Tel 984-287-4066
Fax 919-541-3647
[email protected]
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Jui-Hua Hsieh, Ph.D.
Staff Scientist
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Tel 984-287-3142
[email protected]
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Fred Parham, Ph.D.
Mathematical Statistician
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Tel 984-287-3169
[email protected]
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Trey O. Saddler
Contractor - Data Scientist
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Tel 984-287-3180
[email protected]
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Zicong Wang
Contractor - Software Developer
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Tel 984-287-4494
[email protected]
Recent Publications
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Hari A, AbdulHameed M, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Casey W, Auerbach S, Wallqvist A, Pannala V. Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis.
Frontiers in toxicology.
2024;6:1390196.
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AbstractHari A, AbdulHameed M, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Casey W, Auerbach S, Wallqvist A, Pannala V. Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis. Frontiers in toxicology. 2024
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Pannala V, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S, Wallqvist A. Correction: Pannala et al. High-Throughput Transcriptomics Differentiates Toxic versus Non-Toxic Chemical Exposures Using a Rat Liver Model. Int. J. Mol. Sci. 2023, 24, 17425.
International journal of molecular sciences.
2024 Jun 28;25(13):.
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AbstractPannala V, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S, Wallqvist A. Correction: Pannala et al. High-Throughput Transcriptomics Differentiates Toxic versus Non-Toxic Chemical Exposures Using a Rat Liver Model. Int. J. Mol. Sci. 2023, 24, 17425. International journal of molecular sciences. 2024 Jun 28
]
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Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay.
Chemical research in toxicology.
2024 Jun 17;37(6):923-934.
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AbstractSostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay. Chemical research in toxicology. 2024 Jun 17
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Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver.
Toxicologic pathology.
2023 Oct;51(7-8):470-481.
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AbstractPandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver. Toxicologic pathology. 2023 Oct
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Gant T, Auerbach S, Von Bergen M, Bouhifd M, Botham P, Caiment F, Currie R, Harrill J, Johnson K, Li D, Rouquie D, van Ravenzwaay B, Sistare F, Tralau T, Viant M, van de Laan J, Yauk C. Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity.
Archives of toxicology.
2023 Aug;97(8):2291-2302.
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AbstractGant T, Auerbach S, Von Bergen M, Bouhifd M, Botham P, Caiment F, Currie R, Harrill J, Johnson K, Li D, Rouquie D, van Ravenzwaay B, Sistare F, Tralau T, Viant M, van de Laan J, Yauk C. Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity. Archives of toxicology. 2023 Aug
]
More Recent Publications from PubMed
Software
- Tox21 Toolbox
The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.
