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Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

It is revealed that NK cells, in addition to T cells, mediate the effect of PD-1/PD-L1 blockade immunotherapy, and the importance of this axis in inhibiting NK cell responses in vivo is demonstrated.
Wolters Kluwer (opens in a new tab)

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Neutrophils are identified as key regulators of intraluminal survival and extravasation through their cross-talk with host cells and disseminating carcinoma cells through the secretion of IL1β and matrix metalloproteinases.
PubMed (opens in a new tab)

Recognition of tumors by the innate immune system and natural killer cells.

PubMed (opens in a new tab)

Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies

Several strategies are proposed to potentiate the mAb-mediated ADCC in cancer patients and may enhance anti-cancer therapeutic effects of these regents.
Springer (opens in a new tab)

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors.

It is demonstrated that MHC class I-deficient tumor cells can escape from the immune response by functionally inactivating NK cells, and cytokine-based immunotherapy is suggested as a potential strategy for MHCclass I- deficient tumors.
PubMed (opens in a new tab)

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

P53 induction regulates NK cell recruitment via CCL2, leading to NKG2D-dependent elimination of senescent tumors in mice treated with EMT-naïve mice with programmed cell death.
PubMed (opens in a new tab)

Viral strategies for evading antiviral cellular immune responses of the host

This review article discusses in this review article various strategies that viruses have developed to evade antiviral cellular responses of the host, and unraveling these viral strategies allows a better understanding of thehost‐pathogen interactions and their coevolution.
Wiley (opens in a new tab)

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

It is shown that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection, and this results overturn conventional wisdom that soluble ligands are always inhibitory and suggest a new approach for cancer immunotherapy.
Publisher (opens in a new tab)

Novel associations between activating killer-cell immunoglobulin-like receptor genes and childhood leukemia.

The results show that harboring activating KIR genes is associated with reduced risk for developing B-ALL in Canadian children of white origin, and inheritance of a higher number of activating Kir genes was associated with significant reductions in risk for ALL in children.
PubMed (opens in a new tab)

Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination

How the genes encoding NK cell receptors and their ligands determine innate genetic resistance/susceptibilty of humans against HIV infections and AIDS is discussed and their implications for anti‐HIV immunotherapy and vaccination are discussed.
Wiley (opens in a new tab)
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