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Regulation of ligands for the NKG2D activating receptor.

The numerous pathways that have been implicated in the regulation of NKG2D ligands are reviewed, the pathologic states in which those pathways are likely to act are discussed, and the findings are synthesized into general schemes of NKD ligand regulation in NK cell responses to cancer and infection.
PubMed (opens in a new tab)

Enhancer connectome in primary human cells identifies _target genes of disease-associated DNA elements

It is shown that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and _target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells, providing a principled means of assigning molecular functions to autoimmune and cardiovascular disease risk variants.
Nature (opens in a new tab)

Discovery of stimulation-responsive immune enhancers with CRISPR activation

A discovery platform that can identify stimulus-responsive enhancers for a _target gene independent of stimulus exposure is described and reveals how non-coding variation associated with human immune dysfunction alters context-specific gene programs.
Springer (opens in a new tab)

Recognition of tumors by the innate immune system and natural killer cells.

PubMed (opens in a new tab)

Cornerstones of CRISPR–Cas in drug discovery and therapy

How CRISPR–Cas can affect the next generation of drugs by accelerating the identification and validation of high-value _targets, uncovering high-confidence biomarkers and developing differentiated breakthrough therapies is discussed.
Nature (opens in a new tab)

SLC19A1 transports immunoreactive cyclic dinucleotides

A genome-wide CRISPR-interference screen is used to identify the reduced folate carrier SLC19A1 as the major transporter of cyclic dinucleotides in human cells, with potential roles in immunotherapeutic treatment of cancer, immune responses to pathogens and inflammatory diseases.
Springer (opens in a new tab)

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

It is shown that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection, and this results overturn conventional wisdom that soluble ligands are always inhibitory and suggest a new approach for cancer immunotherapy.
Publisher (opens in a new tab)

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Using a forward genetic screen in a tumor-derived human cell line, several novel factors supporting expression of the NKG2D ligand ULBP1 are identified and offer insight into the stress pathways that alert the immune system to danger.
PubMed (opens in a new tab)

The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells.

PubMed (opens in a new tab)

SLC19A1 is a cyclic dinucleotide transporter

A genome-wide CRISPR interference screen is used to identify the reduced folate carrier SLC19A1 as the major CDN transporter for uptake of synthetic and naturally occurring CDNs, and has far reaching implications for the immunotherapeutic treatment of cancer and certain inflammatory diseases.
Publisher (opens in a new tab)
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