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Assessment of copy-number variation in the NKG2C receptor gene in a single-tube and characterization of a reference cell panel, using standard polymerase chain reaction.

A method for fast, simple and accurate assessment of NKG2C copy-number variation - presence or absence in the genome of an NKG 2C gene, in homo- or heterozygosis, is detected by a single conventional polymerase chain reaction that yields amplicons of different lengths in each genotype.
PubMed (opens in a new tab)

Imprint of human cytomegalovirus infection on the NK cell receptor

(4939 articles) Immunobiology • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information…

Influence of KIR gene diversity on the course of HSV-1 infection: resistance to the disease is associated with the absence of KIR2DL2 and KIR2DS2.

Analysis of the contribution of KIR gene diversity to the variable clinical course of HSV-1 infection by comparing the distribution of these genes in humans with clinical manifestations of the disease with that in asymptomatically infected donors suggests that presence in the genome of Kir2DL2 and KIR2DS2 hinders an effective cellular response to HSv-1.
PubMed (opens in a new tab)

Multiple sclerosis associates with LILRA3 deletion in Spanish patients

It is shown that relapsing MS (R-MS) is associated with a gene deletion affecting the hypothetically soluble leukocyte immunoglobulin (Ig)-like receptor A3 (LILRA3, 19q13.4), in agreement with an earlier finding in German patients, which points to a gene-dose-dependent, protective role for LILra3.
Nature (opens in a new tab)

the CD94/NKG2C killer lectin-like receptor

Data support that HCMV infection selectively shapes the NKR repertoire of NK and T cells from healthy carrier individuals.

Imprint of human cytomegalovirus infection on the NK cell receptor repertoire

This dissertation aims to provide a history of immunobiology from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “black box” disease began to circulate.

NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV

The results demonstrate that host immunogenetics, in particular NKG2C diversity, influences the magnitude of such response to HCMV.
PubMed (opens in a new tab)
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