Skip to search formSkip to main contentSkip to account menu

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

An antigen delivery system _targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
PDF (opens in a new tab)

Inducing and expanding regulatory T cell populations by foreign antigen

The conversion of truly naive CD4+ T cells into suppressor cells expressing Foxp3 is reported by _targeting of peptide-agonist ligands to dendritic cells and by analysis of Foxp 3 expression at the level of single cells, showing that conversion was achieved by minute antigen doses with suboptimal dendrite cell activation.
Springer (opens in a new tab)

Tolerogenic dendritic cells.

It is suggested that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
PubMed (opens in a new tab)

Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance

It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery, and overcomes at least some of the risk of developing autoimmunity and chronic inflammation.
Wiley (opens in a new tab)

Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo.

PubMed (opens in a new tab)

Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.

Recent studies, particularly in experimental mouse systems, that have delineated the integrated mechanisms of crucial immunomodulatory pathways that enable specific populations of DCs and T cells to work intimately together as single functional units that are indispensable for the maintenance of immune homeostasis are reviewed.
PubMed (opens in a new tab)

Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.

PubMed (opens in a new tab)

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

Treatment with globular adiponectin in vivo ameliorated EAE, and was associated with an increase in Treg cells, indicating that adiponECTin is an important regulator of T‐cell functions during EAE.
Wiley (opens in a new tab)

Dendritic Cells As Inducers of Peripheral Tolerance.

PubMed (opens in a new tab)

Natural and Induced Tolerogenic Dendritic Cells

The mechanisms and functions of natural and induced tolerogenic DCs are discussed and further insight is offered into how their possible manipulations may ultimately lead to more precise treatments for various immune-mediated conditions and diseases.
AAI (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)
  NODES
Note 1