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Consensus guidelines for the detection of immunogenic cell death

Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Taylor & Francis (opens in a new tab)

Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.

It is suggested that the expansion of this highly dysfunctional CD56(-)/CD16(+) (CD56(-)) NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population.
PubMed (opens in a new tab)

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

An expansion of the functionally defective CD56-/CD16+ population of NK cells in viremic versus aviremic patients is demonstrated and functional tests confirmed that the abnormal expression of the activating receptors and of iNKRs was associated with a markedly impaired NK cytolytic function.
NAS (opens in a new tab)

Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections.

Evidence is provided for a functional dichotomy in patients with chronic HBV and HCV infections, featuring conserved or enhanced cytolytic activity and dysfunctional cytokine production, which may contribute to virus persistence.
PubMed (opens in a new tab)

The impaired NK cell cytolytic function in viremic HIV‐1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)

The present study indicates that the defective expression of NCR represents at least one of the possible mechanisms leading to the impaired NK cell function in HIV‐1 infection and it can contribute to explain the relatively high frequency of opportunistic tumors reported in cohorts of untreated patients before the occurrence of profound immunosuppression.
Wiley (opens in a new tab)

Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.

It is shown that Vδ1(+) T cells can be selectively induced to express NKp30, NKp44 and NKp46, through a process that requires functional phosphatidylinositol 3-kinase (PI-3K)/AKT signaling on stimulation with γ(c) cytokines and TCR agonists.
PubMed (opens in a new tab)

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

It is shown that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.
Springer (opens in a new tab)

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Novel findings with respect to NCR-mediated functions of NK cells are reviewed and the functional consequences of NCR expression on non-NK cells are discussed, with a particular focus on the T cell compartment.
PubMed (opens in a new tab)

Classification of current anticancer immunotherapies

A critical, integrated classification of anticancer immunotherapies is proposed and the clinical relevance of these approaches is discussed.
PDF (opens in a new tab)

HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts.

Ligands for NK-cell receptors are modulated during the course of HIV infection, which may greatly alter NK cells' ability to kill the infected cells.
PubMed (opens in a new tab)
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