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Endothelin Mediates Superoxide Production and Vasoconstriction through Activation of NADPH Oxidase and Uncoupled Nitric-Oxide Synthase in the Rat Aorta

Experiments tested the hypothesis that elevated levels of endothelin 1 in the vasculature activate NADPH oxidase and/or uncoupled nitric-oxide synthase (NOS), resulting in ET-1-induced increase inbatchmode, and found no effect on ETA and ETB receptor antagonists.
ASPET (opens in a new tab)

NADPH Oxidase Inhibition Attenuates Oxidative Stress but Not Hypertension Produced by Chronic ET-1

Evidence is provided that chronic ET-1 infusion increases vascular NADPH oxidase-dependent superoxide production but does not account for chronic ET–1–induced hypertension.
Wolters Kluwer (opens in a new tab)

Mechanisms of ET-1-mediated 02~ production in the rat aorta

Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats.

Despite sex-specific effects of advancing age on the NOS system and increases in markers of oxidative stress, vascular function is maintained in mesenteric arteries from aged Fischer 344/Brown Norway rats, suggesting that age-related alterations in the resistance vasculature are complex and likely involve multiple compensating vasoactive pathways.
PubMed (opens in a new tab)
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  NODES
Note 1