Neural control of renal function.
The renorenal reflex coordinates the excretory function of the two kidneys so as to facilitate homeostatic regulation of sodium and water balance and proof of principle studies in essential hypertensive patients demonstrate that renal denervation produces sustained decreases in arterial pressure.
Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats
It is suggested that the administration of exogenous H2S lowers the blood pressure and confers protection against the progression of STZ-induced nephropathy in spontaneously hypertensive rats (SHR) that were diabetic.
Phenolic profile and antioxidant activity of various extracts from Citrullus colocynthis (L.) from the Pakistani flora
- A. I. HussainH. Rathore E. Johns
- 1 February 2013
Environmental Science, Medicine
Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats.
The enhanced expression of eNOS in L-arginine treated LVH rats resulted in the amelioration of oxidative and haemodynamic parameters suggesting that NO system is an important therapeutic _target in cardiac and LV hypertrophies.
Obesity depresses baroreflex control of renal sympathetic nerve activity and heart rate in Sprague Dawley rats: role of the renal innervation
- S. A. KhanMunavvar Z. A. Sattar E. Johns
- 1 July 2015
Biology, Medicine
The role of the renal innervation in arterial and cardiopulmonary baroreflex regulation of renal sympathetic nerve activity (RSNA) and heart rate in rats fed a high‐fat diet to induce obesity is investigated.
The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat
- M. AbdullaM. SattarE. Johns
- 12 July 2011
Biology, Medicine
The role played by the renin-angiotensin and sympathetic nervous systems in the haemodynamic alterations that occur due to prolonged consumption of fructose are addressed.
IMPACT OF ISOPRENALINE AND CAFFEINE ON DEVELOPMENT OF LEFT VENTRICULAR HYPERTROPHY AND RENAL HEMODYNAMIC IN WISTAR KYOTO RATS.
- Ashfaq AhmadM. Sattar E. Johns
- 1 September 2015
Medicine
Acta Poloniae Pharmaceutica - Drug Research
Isoprenaline and caffeine (I/C) induces LVH and cardiac hypertrophy with increases in blood pressure, fluid excretion and reduced renal hemodynamics, which is easily generated and associated with low mortality in this disease model.
Renal nerves and nNOS: roles in natriuresis of acute isovolumetric sodium loading in conscious rats.
- E. Kompanowska-JezierskaH. Wolff P. Bie
- 1 April 2008
Biology, Medicine
Acute sodium-driven renin regulation seems independent of RSNA and nNOS under the present conditions, and neither renal denervation nor nN OS inhibition affects either the renin down-regulation or the natriuretic response to acute sodium loading.
Up Regulation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol–Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats
- Ashfaq AhmadM. Sattar E. Johns
- 10 March 2016
Medicine
This CSE/H2S pathway exhibits an antihypertrophic role by antagonizing the hypertrophic actions of angiotensin II(Ang II) and noradrenaline but attenuates oxidative stress and improves pulse wave velocity which helps to suppress LVH.
Renal functional & haemodynamic changes following acute unilateral renal denervation in Sprague Dawley rats.
- I. M. SalmanM. Sattar E. Johns
- 2010
Biology, Medicine
Renal sympathetic nerves serve more important role in salt and water conservation than in dynamic autoregulation of RBF under normal sympathetic tone; yet, their effects on renal haemodynamics become more evident in the presence of augmented renal sympathetic nerve activity (RSNA).
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