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Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

ACE-deficient animals demonstrate the role of this enzyme in systemic blood pressure, renal development and function, and male fertility as well as the importance of testis ACE in male fertility.
PubMed (opens in a new tab)

The critical role of tissue angiotensin-converting enzyme as revealed by gene _targeting in mice.

These studies strongly support the concept that the tissue-bound ACE is essential to the control of blood pressure and the structure and function of the kidney.
PubMed (opens in a new tab)

The Role of Angiotensin-Converting Enzyme in Blood Pressure Control, Renal Function, and Male Fertility

Elsevier (opens in a new tab)

Effects of α‐thalassemia‐2 on the developmental changes of hematological values in children with sickle cell disease from georgia

The interaction of α‐thalassemia and Hb F in young SS patients may be more complex than revealed by Hbf F levels in cell lysates, and among older SS children (> 7 years) α-thalassemi and HB F levels exceeding 15% appear to have additive effects in diminishing the rate of hemolysis.
Wiley (opens in a new tab)

Different ζ globin gene deletions among Black Americans

Hematologic data on carriers of the ζ globin gene deletions in association with Hb AS, SS, and SC suggest that these deletions have no effect on the function of the adult α globin genes.
Springer (opens in a new tab)

Different zeta globin gene deletions among black Americans.

Hematologic data on carriers of the zeta globin gene deletions in association with Hb AS, SS, and SC suggest that these deletions have no effect on the function of the adult alpha globin genes.
PubMed (opens in a new tab)

Isolation and Characterization of Mannitol Non-Utilizing Mutants of Neurospora crassa

Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element.

These experiments prove that the CRE-like element is essential for testis ACE promoter activity, although it does not appear to be responsible for its tissue specificity, and provide insight into how a phenotypically differentiated tissue, ie, male gem cells, regulate tissue-specific gene expression.
PubMed (opens in a new tab)

Insulin and glucocorticoids regulate IGFBP-1 expression via a common promoter region.

Hepatic expression of insulin-like growth factor binding protein-1 is regulated by insulin and glucocorticoids and transfection of rat hepatocytes in primary culture should be a useful approach for exploring the regulation of gene expression by insulin.
PubMed (opens in a new tab)
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  NODES
Association 2
Note 1