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Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

It is shown here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that thisosphorylation is associated with increased activity of Jak2.
Nature (opens in a new tab)

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

The isolation by expression cloning of a complementary DNA encoding a unique protein with the pharmacological specificity of a vascular AT1 receptor is reported, and hydropathic modelling of the deduced protein suggests that it shares the seven-transmembrane-region motif with the G protein-coupled receptor superfamily.
Springer (opens in a new tab)

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

Knowing the structural differences between the two ACE domains should allow clinicians to envision new therapies for diseases not currently treated with ACE inhibitors, and these reagents will undoubtedly be powerful tools for probing the physiologic actions of each ACE domain.
Publisher (opens in a new tab)

_targeting genes for self-excision in the germ line.

A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme…
PubMed (opens in a new tab)

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

ACE-deficient animals demonstrate the role of this enzyme in systemic blood pressure, renal development and function, and male fertility as well as the importance of testis ACE in male fertility.
PubMed (opens in a new tab)

Nodular (Pseudosarcomatous) fasciitis, a nonrecurrent lesion: Clinicopathologic study of 134 cases

Though all lesions were histologically reminiscent of reparative mesenchymal tissue, four subtypes—the reactive type, the densely cellular type, those with osteoid or cartilaginous metaplasia, and the so‐called proliferative fasciitis—were distinguished from the majority of lesions that conform to the description given by Kornwaler.
Wiley (opens in a new tab)

The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.

PubMed (opens in a new tab)

ACE and ACE2 Activity in Diabetic Mice

In renal cortex from diabetic mice, ACE2 expression is increased at the posttranscriptional level, and this should be helpful in the evaluation of kidney-specific alterations in the balance of these two carboxypeptidases.
ADA (opens in a new tab)

DC isoketal-modified proteins activate T cells and promote hypertension.

The data reveal that hypertension activates dendritic cell activation of T cells, in large part by promoting the formation of isoketals, and suggest that reducing isokets has potential as a treatment strategy for this disease.
PubMed (opens in a new tab)

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor*

The binding of the AT1A receptor to the intracellular tyrosine kinase Jak2 supports the concept that the seven-transmembrane superfamily of receptors can physically associate with enzymatically active intrace cellular proteins, creating a signaling complex mechanistically similar to that observed with growth factor and cytokine receptors.
ASBMB (opens in a new tab)
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  NODES
Association 1
Note 1