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Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease

The purpose of this article is to review the current understanding of CD57 expression as a marker of NK cell function and disease prognosis, as to outline areas for further research.
PubMed (opens in a new tab)

Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection

The data indicate that attenuated or live viral vaccines promote cytokine-induced memory-like NK cells and that this process is influenced by HCMV infection.
AAI (opens in a new tab)

Increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment

Aliment Pharmacol Ther 2011; 33: 115–126
Wiley (opens in a new tab)

Human peripheral blood γδ T cells respond to antigens of Plasmodium falciparum

Peripheral blood lymphocytes from donors previously unexposed to malaria parasites proliferate in vitro when stimulated with whole parasitized red blood cells of several different strains of…
Publisher (opens in a new tab)

The contribution of cytomegalovirus to changes in NK cell receptor expression in HIV-1-infected individuals.

PubMed (opens in a new tab)

Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy

Investigation of the relationship between HIV-1 viraemia and changes in C-type lectin-like receptor expression in NK cells and the effect of highly active antiretroviral therapy (HAART) found changes in the NK cell repertoire resembled those associated with concomitant infections.
Wolters Kluwer (opens in a new tab)

Cytokine profiles for human V gamma 9+ T cells stimulated by Plasmodium falciparum.

Exposure to interferon-gamma and TNF-alpha speaks for a cytolytic and/or inflammatory role of gamma delta cells in the response to malaria in non-exposed individuals.
PubMed (opens in a new tab)

PD-1 expression on natural killer cells and CD8(+) T cells during chronic HIV-1 infection.

Raised levels of PD-1 were associated with limited NK cell proliferation, which may have consequences for their maintenance during chronic HIV-1 infection.
PubMed (opens in a new tab)

Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.

These changes coincided with a highly significant drop in anti-HCMV IgG titers by the age of 10 years, suggesting that HCMV infection is brought under control as NK cells differentiate (or vice versa), and lack of expression of NKG2C may be associated with altered control of H CMV in childhood.
PubMed (opens in a new tab)

Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals

Chronic HIV-1 infection results in depletion of both natural killer cells and CD4+ T cells in colonic tissue and antiretroviral therapy results in a recovery of these subsets in individuals with undetectable plasma viral load.
Wolters Kluwer (opens in a new tab)
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