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Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

It is shown here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that thisosphorylation is associated with increased activity of Jak2.
Nature (opens in a new tab)

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src*

The results suggest that NO and PGI2 function in parallel in mediating the effects of VEGF, and that Src activation is required for V EGF induction of phospholipase C γ1 activation and inositol 1,4,5-trisphosphate formation.
ASBMB (opens in a new tab)

Janus kinase 2, an early _target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.

Evidence that nicotine stimulation of alpha7 nAChR transduces signals to phosphatidylinositol 3-kinase and Akt via Janus kinase 2 (JAK2) in a cascade, which results in neuroprotection is provided.
PubMed (opens in a new tab)

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor*

The binding of the AT1A receptor to the intracellular tyrosine kinase Jak2 supports the concept that the seven-transmembrane superfamily of receptors can physically associate with enzymatically active intrace cellular proteins, creating a signaling complex mechanistically similar to that observed with growth factor and cytokine receptors.
ASBMB (opens in a new tab)

Novel Mechanism of Activation of NADPH Oxidase 5

The phosphorylation of Nox5 at key residues facilitates enzyme activation at lower levels of intracellular calcium and may provide an avenue for enzyme activation in response to a greater variety of extracellular stimuli.
ASBMB (opens in a new tab)

Role of the JAK/STAT signaling pathway in diabetic nephropathy.

This review focuses on some of the key elements in the diabetic microenvironment, especially high glucose and the accumulation of advanced glycoxidation end products and considers their impact on ANG II and other vasoactive peptide-mediated signaling events in vitro and in vivo.
PubMed (opens in a new tab)

Janus Kinase 2, an Early _target of α7 Nicotinic Acetylcholine Receptor-mediated Neuroprotection against Aβ-(1–42) Amyloid*

Evidence is provided that nicotine stimulation of α7 nAChR transduces signals to phosphatidylinositol 3-kinase and Akt via Janus kinase 2 (JAK2) in a cascade, which results in neuroprotection, suggesting a pivotal role for JAK2.
ASBMB (opens in a new tab)

Role of Janus Kinase/Signal Transducer and Activator of Transcription and Mitogen-activated Protein Kinase Cascades in Angiotensin II- and Platelet-derived Growth Factor-induced Vascular Smooth…

Electroporation of antibodies against MEK1 or ERK1 abolished vascular smooth muscle cell proliferation in response to either platelet-derived growth factor or angiotensin II, and AG-490, a specific inhibitor of the JAK2 tyrosine kinase, prevented proliferation of vascular smoother muscle cells.
ASBMB (opens in a new tab)

Inhibition of the JAK/STAT Signaling Pathway Prevents the High Glucose-Induced Increase in TGF-β and Fibronectin Synthesis in Mesangial Cells

Results provide direct evidence for linkages between JAK2, STAT1, and the glucose-induced overproduction of TGF-β and fibronectin in GMC.
Publisher (opens in a new tab)

Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.

It is demonstrated that hyperglycemia induces activation of JAK2 and the STATs in vivo via an ANG II-dependent mechanism and that these proteins may be involved in the early kidney damage associated with diabetes.
PubMed (opens in a new tab)
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  NODES
Association 1
Note 1