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Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study

Elsevier (opens in a new tab)

Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial

At 21.2 years of follow-up of a 7.8 years intensified, multifactorial, _target-driven treatment of type 2 diabetes with microalbuminuria, the patients in the intensive-therapy group survived for a median of 7.9  years of gain of life, matched by time free from incident cardiovascular disease.
Springer (opens in a new tab)

Limited impact of lifestyle education in patients with Type 2 diabetes mellitus and microalbuminuria: results from a randomized intervention study

SUMMARY
Wiley (opens in a new tab)

Impact of socioeconomic position on initiation of SGLT-2 inhibitors or GLP-1 receptor agonists in patients with type 2 diabetes – a Danish nationwide observational study

PubMed (opens in a new tab)

Cost-Effectiveness of Intensified Versus Conventional Multifactorial Intervention in Type 2 Diabetes

Intensive therapy was more cost-effective than conventional treatment in Denmark and became dominant (cost- and lifesaving) from a health care payer perspective in Denmark.
ADA (opens in a new tab)

Plasma N-terminal pro-brain natriuretic peptide as a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria

It is concluded that high plasma NT-proBNP is a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria.
Springer (opens in a new tab)

Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

In individuals with T2D and albuminuria, higher choline, carnitine and a weighted sum of four metabolites from the TMAO pathway were risk markers for deterioration in renal function during long-term follow-up.
PDF (opens in a new tab)

Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study

Intensified, multifactorial intervention for 7.8 years in type 2 diabetic individuals with microalbuminuria reduced the risk of hospitalisation for heart failure by 70% during a total of 21.2 years of observation.
Springer (opens in a new tab)

Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits.

PubMed (opens in a new tab)

The economic burden of poor glycemic control associated with therapeutic inertia in patients with type 2 diabetes in Denmark

It is highlighted that efforts to minimize therapeutic inertia, by securing timely intensification before individual HbA1c _targets are exceeded, results in significant long-term cost savings in Denmark.
Taylor & Francis (opens in a new tab)
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