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Dendritic cells and the control of immunity

Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis and the realization that these cells are a powerful tool for manipulating the immune system is realized.
Nature (opens in a new tab)

The dendritic cell system and its role in immunogenicity.

Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
PubMed (opens in a new tab)

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

This work _targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies and found that this difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
AAAS (opens in a new tab)

Proliferating dendritic cell progenitors in human blood

Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
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Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

An antigen delivery system _targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
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DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells primarily at the immature stage of their differentiation and DC-SIGN, a C-type lectin, may be considered as a new _target for designing therapies that block dengue infection.
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Taking dendritic cells into medicine

Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Nature (opens in a new tab)

Dendritic Cells Specialized and Regulated Antigen Processing Machines

Elsevier (opens in a new tab)

Efficient _targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral…

DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.
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The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies

The p150, 90 heterodimer is the major beta 2 integrin of spleen dendritic cells, and it is speculated that it may function to localize these APC at sites that permit access to the recirculating pool of resting T cells.
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