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Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease.

It is shown that spironolactone may reduce proteinuria and retard renal progression in chronic kidney disease patients and the monthly rate of decrease in estimated glomerular filtration rate from baseline was lower in patients treated with spironOLactone than in controls.
PubMed (opens in a new tab)

"Zero ischemia" partial nephrectomy: novel laparoscopic and robotic technique.

PubMed (opens in a new tab)

Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study.

This study shows that spironolactone may effectively reduce proteinuria in patients with CKD and concerns remain in regard to the risk for hyperkalemia in patientswith CKD.
PubMed (opens in a new tab)

Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity.

The notion that ROS may raise BP via activation of the SNS through downregulation of nNOS and NO production is supported, in part by mechanisms independent of NO.
PubMed (opens in a new tab)

The Importance of Understanding the Stages of COVID-19 in Treatment and Trials.

relevant stages of COVID-19 are identified including three periods: pre-exposure; incubation, and detectable viral replication, and five phases: the viral symptom phase, the early inflammatoryphase, the secondary infection phase,The multisystem inflammatory phase, and the tail phase, which should serve as a framework to guide when CO VID-19 therapeutics are likely to provide benefit rather than harm.
PubMed (opens in a new tab)

Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat.

PubMed (opens in a new tab)

Renal afferent impulses, the posterior hypothalamus, and hypertension in rats with chronic renal failure.

It is shown that afferent impulses from an injured kidney increase NE secretion from the posterior hypothalamus and raise blood pressure, which appears to be an important integrative structure of the sympathetic regulation of blood pressure.
PubMed (opens in a new tab)

Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension.

No correlation was found between UAE and MAP or creatinine clearance, and long-term prospective studies are needed to extablish whether an increase in UAE may predict future nephrosclerosis in essential hypertension.
PubMed (opens in a new tab)

Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension

It is suggested that hypertensive individuals with microalbuminuria manifest a greater incidence of cardiovascular events and a greater decline in renal function than do patients with normal UAE.
Wolters Kluwer (opens in a new tab)

A controlled, prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease.

It is shown that treatment with atorvastatin in addition to a regimen with ACE inhibitors or ARBs may reduce proteinuria and the rate of progression of kidney disease in patients with chronic kidney disease, proteinuria, and hypercholesterolemia.
PubMed (opens in a new tab)
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