Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection

@article{Brunetta2010ChronicHV,
  title={Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection},
  author={Enrico Brunetta and Manuela Fogli and Stefania Varchetta and Luisa Bozzo and K Hudspeth and Emanuela Marcenaro and Alessandro Moretta and Domenico Mavilio},
  journal={AIDS},
  year={2010},
  volume={24},
  pages={27–34},
  url={https://api.semanticscholar.org/CorpusID:44600822}
}
The inversion of NKG2A/NKG2C ratio characterizes advanced stages of HIV-1 disease in patients showing a concomitant HCMV infection and renders this cohort of patients distinguishable from LTNPs and early HIV- 1- infected individuals.
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137 Citations
Highly Influential Citations
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Background Citations
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137 Citations

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NKG2C+NKG2A− Natural Killer Cells are Associated with a Lower Viral Set Point and may Predict Disease Progression in Individuals with Primary HIV Infection

The experimental results allow us to draw the conclusion that NKG2C+ NK cells might exert an antiviral effect and that the proportion of NKG 2C+NKG2A− NK cells, and the ratio of NK G2C/NKG 2A, are potential biomarkers for predicting HIV disease progression.

The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection.

Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals

The abundance of highly functional CD57+NKG2C+ NK cells in HIV-1-infected individuals raises the possibility that these NK cells could play a role inAIDS pathogenesis or serve as effector cells for therapeutic/cure strategies.

Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56-CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection.

HIV-1 infection induces the expansion of the CD56negative NK cell subset marked by altered receptor expression profiles that are indicative of impaired function and may explain the overall NK cell dysfunction observed in chronic HIV-1 infections.

Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals

The general phenotypic and functional equivalency observed suggests NKG2C-independent routes of HCMV-driven NK cell differentiation, which may involve increased CD2 expression, are suggested.

Natural Killer Cells in Human Immunodeficiency Virus-1 Infection: Spotlight on the Impact of Human Cytomegalovirus

The evidence in favor of “adaptive” changes likely induced by HCMV co-infection in NK-cell subsets is reviewed, highlighting a number of key questions and how insights into the adaptive behavior of NK cells will inform new strategies exploiting their unique properties in the fight against HIV-1.

Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK‐cell subset distribution in children

Novel insights are provided on the impact of HCMV infection on the homeostasis of the NK‐cell compartment in children, revealing a modulatory influence of NKG2C copy number.

NKG2C zygosity influences CD94/NKG2C receptor function and the NK‐cell compartment redistribution in response to human cytomegalovirus

A mechanistic interpretation on the way the NKG2C genotype influences steady‐state NKG 2C+ NK‐cell numbers is provided, further supporting an active involvement of the receptor in the HCMV‐induced reconfiguration of the NK‐ cell compartment.

NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1

It is shown that NK cells can obtain CCR5 and CXCR4, but barely CD4, from T cell lines by trogocytosis in vitro, suggesting thatNK cells are actively fighting against HIV-1 infection in viremic and aviremic patients.
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18 References

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The conclusion that changes in the NKR repertoire in HIV1-positive patients are related to a concomitant HCMV infection is supported.

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