Role of nitric oxide in regulation of renal sympathetic nerve activity during hemorrhage in conscious rats.

@article{Fujisawa1999RoleON,
  title={Role of nitric oxide in regulation of renal sympathetic nerve activity during hemorrhage in conscious rats.},
  author={Yoshihide Fujisawa and N Mori and Kouichi Yube and Hiroshi Miyanaka and Akira Miyatake and Youichi Abe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1999},
  volume={277 1},
  pages={H8-H14},
  url={https://api.semanticscholar.org/CorpusID:4517253}
}
The results indicate that NO modulated HR and RSNA responses to hemorrhage but did not directly affect the baroreceptor reflex arch, suggesting it can be assumed that No modulated thebaroreflex function by altering the secretion of vasopressin induced by hemorrhage.
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17 Citations
Background Citations
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Methods Citations
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17 Citations

Nitric oxide synthases are involved in the modulation of cardiovascular adaptation in hemorrhaged rats.

Renal Sympathetic Nerve Responses to Tempol in Spontaneously Hypertensive Rats

It is suggested that augmented superoxide production contributes to the development of hypertension through activation of the sympathetic nervous system through the use of superoxide dismutase mimetic Tempol.

Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus.

The baroregulation of arginine vasopressin (AVP) gene transcription in the supraoptic and paraventricular nuclei in conscious rats by use of intronic in situ hybridization indicates that AVP gene transcription increases rapidly after both hypotensive hemorrhage and normovolemic hypotension.

Nitric oxide modulates arterial baroreflex control of heart rate in conscious lambs in an age-dependent manner.

The data provide new information that age-dependent effects of the arterial baroreflex appear to result from effects of endogenously produced NO.

Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy.

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Hypovolemic state: involvement of nitric oxide in the aged related alterations of aquaporins-2 abundance in rat kidney.

Thyroid disorders and nitric oxide in cardiovascular adaptation to hypovolemia.

Thyroid disorders were associated with hypertrophic remodelling which impacted differently on cardiac function and its adaptation to a hypovolemia triggered a nitric oxide synthase activation modulating the heart function to maintain haemodynamic homeostasis.

Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats

Results indicate that signals transmitted by ARNs have an important role in the control of systemic hemodynamics through regulating central RAS-mediated changes in sympathetic nerve activity.

Effects of a New Calcium Channel Blocker, Azelnidipine, on Systemic Hemodynamics and Renal Sympathetic Nerve Activity in Spontaneously Hypertensive Rats

Data suggest that azelnidipine possesses sympathoinhibitory effects, which may be one reason why it had less pronounced effects on HR in hypertensive patients.

Age-Related Changes of Cardiac Caveolins and Nitric Oxide Synthase Modulation during Hypovolemic State

The increased production of NO during hypovolemic state depends on the presence of cav-1 which plays a key role in the aging process.

31 References

Role of nitric oxide in regulation of baroreceptor reflex.

Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats.

It is demonstrated that blunted baroreceptor reflex function in conscious spontaneously hypertensive rats is mediated by an Ang II type 1 receptor.

Role of vasopressin on cardiovascular changes during hemorrhage in conscious rats.

The results indicate that when the plasma concentration of AVP is extremely high during hemorrhage, vasopressin via V1 receptor contributes to BP recovery by the peripheral vasoconstriction and exerts an inhibitory action on RSNA, and vasoppressin through V2 receptor exerts opposite stimulatory action onRSNA.

Role of Sympathetic Nerve Activity in the Generation of Vascular Nitric Oxide in Urethane‐Anesthetized Rats

The results suggest that the sympathetic nervous system plays an important role in modulating the synthesis or release of vascular nitric oxide through the effects of normal sympathetic discharge, humoral activation of α-adrenergic receptors, and 3) vascular tone per se.

Effect of inhibition of nitric oxide synthesis on vasopressin secretion in conscious rabbits.

NO synthase is present in magnocellular neurons of supraoptic and paraventricular nuclei as well as in the posterior pituitary gland and may participate in control of vasoppressin secretion and vasopressin responses to increased plasma osmolality and decreased blood pressure.

Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo.

The pressor effects of intravenously administered noradrenaline during RVLM cooling were markedly potentiated by L-NAME and attenuated by the NO-donor compound S-nitroso-N-acetylpenicillamine (SNAP).

Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity.

The data indicate that endogenous nitric oxide within the PVN regulates sympathetic outflow via some inhibitory mechanisms, which may contribute to elevated sympathetic nerve activity observed during various diseases states such as heart failure and hypertension.

Effect of inhibition of nitric oxide synthesis on the cardiovascular and endocrine responses to hemorrhage in conscious rabbits.

Investigation of the effects of inhibiting nitric oxide synthesis on the cardiovascular, renin and vasopressin responses to hypotensive hemorrhage found that L-NAME markedly attenuated the hypotensive response to hemorrhage, but did not alter the increases in heart rate, plasma renin activity or plasma vasoppressin concentration.

Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits.

The results suggest that in rabbits NO is involved in the mechanism in the NTS that mediates tonic inhibition of RSNA and thus contributes to control of sympathetic nerve activity in rabbits.

NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?

NMA, a selective inhibitor of NO synthesis from L-arginine, was investigated on sympathetic renal nerve activity, blood pressure, and heart rate in the anesthetized rat and baroreceptor deafferentation markedly altered these responses to NMA.

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