Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats.

@article{Xu2001NitricOE,
  title={Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats.},
  author={H Xu and Gregory D. Fink and A. Chen and Stephanie W. Watts and James J. Galligan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 2},
  pages={
          H975-80
        },
  url={https://api.semanticscholar.org/CorpusID:12881433}
}
In conclusion, depressor responses caused by tempol are mediated, partly, by sympathoinhibition in urethane-anesthetized, normotensive rats.
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24 References

Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits.

The results suggest that endogenous NO decreases baroreflex control of HR and RSNA, and both sympathetic and parasympathetic components play a role in the effects of NO on the barore Flexibility.

Effects of dexmedetomidine, an alpha2-adrenoceptor agonist, on renal sympathetic nerve activity, blood pressure, heart rate and central venous pressure in urethane-anesthetized rabbits.

Central infusion of L-arginine or superoxide dismutase does not alter arterial pressure in SHR.

The hypothesis that chronic L-arginine deficiency or the enhanced degeneration of NO by superoxide radicals in the central nervous system contributes to the maintenance of arterial pressure in SHR is not supported.

Dose-dependent effects of propofol on renal sympathetic nerve activity, blood pressure and heart rate in urethane-anesthetized rabbits.

Chronic oxidative stress in the RVLM modulates sympathetic control of circulation in pigs

It is suggested that excitatory actions of oxidative stress contribute significantly to the generation of baseline sympathetic tone in the RVLM during long-term treatment with organic nitrates, and similar mechanisms could promote sympathetictone in cardiovascular diseases that are associated with endogenous oxidative stress for longer periods.

Systemic and Regional Hemodynamic Responses to Tempol in Angiotensin II–Infused Hypertensive Rats

The results suggest that in this model of hypertension, oxidative stress may have contributed to the alterations in systemic blood pressure and regional vascular resistance through inactivation of NO.

Nitro-L-arginine analogues. Dose- and time-related nitric oxide synthase inhibition in brain.

It is suggested that administration of L-NAME and L-NNA diminishes brain NOS activity in a dose- and time-dependent manner and that the duration of effect is at least 6 hours.

Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.

The data implicate O2- in the hypertension of SHR in vivo and suggest that the antihypertensive action of tempol depends on NO synthesis presumably because O 2- inactivates NO and thus diminishes its vasodilatory actions.

Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha.

The SHR is a model of hypertension and renal vasoconstriction associated with oxidative stress and a role for oxygen radicals in the maintenance of hypertension inSHR is suggested.

Effects of induced hypothermia on renal sympathetic nerve activity and baroreceptor reflex in urethane-anesthetized rabbits

Hemodynamics and RSNA during induced hypothermia are regulated by mechanisms other than the baroreceptor reflex system, possibly the dermal cold receptors.

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