Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK‐cell subset distribution in children

@article{Noyola2012InfluenceOC,
  title={Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK‐cell subset distribution in children},
  author={Daniel E. Noyola and Cl{\`a}udia Fortuny and Aura Muntasell and Antoni Noguera-Julian and Carmen Mu{\~n}oz-Almagro and Ana Alarcon and Teresa Juncosa and Manuela Moraru and Carlos Vilches and Miguel L{\'o}pez-Botet},
  journal={European Journal of Immunology},
  year={2012},
  volume={42},
  url={https://api.semanticscholar.org/CorpusID:205789401}
}
Novel insights are provided on the impact of HCMV infection on the homeostasis of the NK‐cell compartment in children, revealing a modulatory influence of NKG2C copy number.
View on Wiley
onlinelibrary.wiley.com
95 Citations
Highly Influential Citations
6
Background Citations
38
Methods Citations
1
Results Citations
4

95 Citations

Relationship of NKG2C Copy Number with the Distribution of Distinct Cytomegalovirus-Induced Adaptive NK Cell Subsets

The characterization of adaptive NK cell subsets that differentiate in response to HCMV is extended, supporting a relationship between their distribution and NKG2C copy number and FcRγ levels and enhanced potential for cytokine production are uncoupled.

Dynamics of the NK-cell subset redistribution induced by cytomegalovirus infection in preterm infants.

The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection.

Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.

These changes coincided with a highly significant drop in anti-HCMV IgG titers by the age of 10 years, suggesting that HCMV infection is brought under control as NK cells differentiate (or vice versa), and lack of expression of NKG2C may be associated with altered control of H CMV in childhood.

NKG2C zygosity influences CD94/NKG2C receptor function and the NK‐cell compartment redistribution in response to human cytomegalovirus

A mechanistic interpretation on the way the NKG2C genotype influences steady‐state NKG 2C+ NK‐cell numbers is provided, further supporting an active involvement of the receptor in the HCMV‐induced reconfiguration of the NK‐ cell compartment.

Adaptive reconfiguration of the human NK‐cell compartment in response to cytomegalovirus: A different perspective of the host‐pathogen interaction

The precise role of NKG2C+ cells in the control of HCMV infection, the molecular mechanisms underlying the NK‐cell compartment redistribution, as well as its putative influence in the response to other pathogens and tumors remain open issues.

Comparative analysis of NK cell receptor repertoire in adults and very elderly subjects with cytomegalovirus infection.

NKG2C gene deletion in the Mexican population and lack of association to respiratory viral infections

The results indicate that copy number variation in the NKG2C gene has no impact on the severity of respiratory viral infections.

Spotlight on NKG2C and the human NK‐cell response to CMV infection

Examining NK‐cell responses in a unique cohort of young children with asymptomatic and symptomatic congenital CMV infection sheds new light on the role of NKG2C copy number variation on the human NK‐ cell response toCMV infection.

NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV

The results demonstrate that host immunogenetics, in particular NKG2C diversity, influences the magnitude of such response to HCMV.
...

61 References

Influence of human cytomegalovirus infection on the NK cell receptor repertoire in children

Data reveal that hCMV may have a profound influence on the NKR repertoire in early childhood, and excretion of the virus was associated with higher proportions of NKG2C+ NK cells.

Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients.

The conclusion that changes in the NKR repertoire in HIV1-positive patients are related to a concomitant HCMV infection is supported.

Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts.

The data support that the interaction of CD94/NKG2C with HCMV-infected fibroblasts, concomitant to the inhibition of human leukocyte antigen (HLA) class I expression, promotes an outgrowth of CD 94/NKg2C(+) NK cells.

Imprint of human cytomegalovirus infection on the NK cell receptor repertoire.

Data support that HCMV infection selectively shapes the natural killer cell receptor (NKR) repertoire of NK and T cells from healthy carrier individuals.

The CD94/NKG2C-expressing NK cell subset is augmented in chronic lymphocytic leukemia patients with positive human cytomegalovirus serostatus.

HCMV infection seemingly shapes the NK cell system in healthy individuals, HIV patients, and B-CLL patients in a uniform manner, even though these involve different immunological challenges.

Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus

The data support the notion that NKG2D functions as a prototypic costimulatory receptor in a subset of HCMV‐specific CD4+ T lymphocytes and thus may have a role in the response against infected HLA class II+ cells displaying NKG 2D ligands.

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection

The inversion of NKG2A/NKG2C ratio characterizes advanced stages of HIV-1 disease in patients showing a concomitant HCMV infection and renders this cohort of patients distinguishable from LTNPs and early HIV- 1- infected individuals.

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.

CMV drives clonal expansion of NKG2C+ NK cells expressing self‐specific KIRs in chronic hepatitis patients

It is shown that HCMV seropositivity was associated with a profound expansion of NKG2C+CD56dim NK cells in patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, shedding new light on how the human NK‐cell compartment adjusts to HCMv infection.

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.

The kinetics of the NK-cell response to CMV reactivation in human recipients after hematopoietic cell transplantation is characterized to support the emerging concept that CMV-induced innate memory-cell populations may contribute to malignant disease relapse protection and infectious disease control long after transplantation.
...

Related Papers

Showing 1 through 3 of 0 Related Papers