DOI:10.1093/cei/uxac082 - Corpus ID: 252010117
Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals
@article{Kristensen2022PhenotypicAF, title={Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals}, author={Anne B. Kristensen and Kathleen M. Wragg and Hillary A. Vanderven and Wen Shi Lee and Julie Silvers and Helen E. Kent and Michael D. Grant and Anthony D. Kelleher and Jennifer A. Juno and Stephen J. Kent and Matthew S. Parsons}, journal={Clinical and Experimental Immunology}, year={2022}, volume={210}, pages={163 - 174}, url={https://api.semanticscholar.org/CorpusID:252010117} }
- Anne B. Kristensen, Kathleen M. Wragg, M. Parsons
- Published in Clinical and Experimental… 2 September 2022
- Medicine
The abundance of highly functional CD57+NKG2C+ NK cells in HIV-1-infected individuals raises the possibility that these NK cells could play a role inAIDS pathogenesis or serve as effector cells for therapeutic/cure strategies.
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It is shown that persistent immune activation during chronic viral co-infections interferes with the functional phenotype of NK cells by modulating the Tim-3 pathway; a decrease inTim-3 expression combined with the acquisition of inhibitory receptors skewed NK cells toward an exhausted and cytotoxic phenotype in an inflammatory environment during chronic HIV infection.
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