Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.

@article{Foley2012CytomegalovirusRA,
  title={Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.},
  author={Bree A Foley and Sarah Cooley and Michael R. Verneris and Michelle Pitt and Julie M. Curtsinger and Xianghua Luo and Sandra L{\'o}pez-Verg{\`e}s and Lewis L. Lanier and Daniel J. Weisdorf and Jeffrey S. Miller},
  journal={Blood},
  year={2012},
  volume={119 11},
  pages={
          2665-74
        },
  url={https://api.semanticscholar.org/CorpusID:206906322}
}
The kinetics of the NK-cell response to CMV reactivation in human recipients after hematopoietic cell transplantation is characterized to support the emerging concept that CMV-induced innate memory-cell populations may contribute to malignant disease relapse protection and infectious disease control long after transplantation.
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Monitoring the phenotype of NK cells post-lung transplant may be a useful biomarker for monitoring patient levels of CMV immunity.

Impact of HCMV Infection on NK Cell Development and Function after HSCT

It appears that the development of NK cells and the distribution of NK cell receptors can be deeply influenced by HCMV infection, and the emergence of so called “memory-like” or “long-lived” NK cells has been documented.

Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays

Investigating the role of a population of innate cells, the adaptive Natural Killer (NK) cells, in the response to HCMV reactivation after hematopoietic stem cell transplantation revealed that adaptive NK cells are modulated in response toHCMV reactsivation after HSCT, and shows their ability to eliminate H CMV-infected _target cells after in vitro expansion.

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

The data identify epigenetic imprinting of the IFNG locus as selective hallmark and crucial mechanism driving strong and stable IFN-γ expression in HCMV-specific NK cell expansions, providing a molecular basis for the regulation of adaptive features in innate cells.

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients

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40 References

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.

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The data support that the interaction of CD94/NKG2C with HCMV-infected fibroblasts, concomitant to the inhibition of human leukocyte antigen (HLA) class I expression, promotes an outgrowth of CD 94/NKg2C(+) NK cells.

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It is revealed that the NK cells generated after haplomismatched SCT are blocked at an immature state characterized by specific phenotypic features and impaired functioning, having potential impact for immune responsiveness and transplantation outcome.

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Inflammatory cytokine production and cytotoxic function do not consistently coexist in NK cells reconstituting after allo-HCT, suggesting a role for T cells in NK education.

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Adaptive Immune Features of Natural Killer Cells

A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.

A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.

How receptor acquisition correlates with the functional maturation of natural killer (NK) cells is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) assays to compare…

NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2–11-Mediated HLA Class I Down-Regulation1

Deletion of UL40 had no significant effect on lysis of infected cells by NK cells, indicating that the expected enhancement of HLA-E expression by specific peptides derived from HCMV-encoded gpUL40 leader sequences was insufficient to confer _target cell protection.

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection

The inversion of NKG2A/NKG2C ratio characterizes advanced stages of HIV-1 disease in patients showing a concomitant HCMV infection and renders this cohort of patients distinguishable from LTNPs and early HIV- 1- infected individuals.

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