Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.

@article{Li1994EffectOA,
  title={Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.},
  author={J S Li and Richard W. Lariviere and Ernesto L. Schiffrin},
  journal={Hypertension},
  year={1994},
  volume={24 2},
  pages={
          183-8
        },
  url={https://api.semanticscholar.org/CorpusID:18980069}
}
It is concluded that a role for endothelin in the elevation of blood pressure and vascular hypertrophy and remodeling in DOCA-salt hypertensive rats may be suggested.
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Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats.

Antihypertensive effect of an endothelin receptor antagonist in DOCA‐salt spontaneously hypertensive rats

Endothelin‐1 mRNA abundance and content of immunoreactive endothelin were increased in the aorta and the mesenteric arterial bed of DOCA‐salt SHR, and were unaffected by treatment with bosentan, supporting the hypothesis of a role of endotheli‐1 in blood pressure elevation in this hypertensive model with malignant hypertension.

Coronary vascular reactivity is improved by endothelin A receptor blockade in DOCA-salt hypertensive rats.

Data indicate that ET-1 plays an important role in coronary vascular dysfunction associated with DOCA-salt hypertension and ETAreceptor blockade impairs the development of hypertension and improves coronary vascular reactivity.

Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist.

Treatment with the combined endothelin type A/endothelin types A and B receptor antagonist bosentan moderately reduced blood pressure rise and nearly completely blunted the development of vascular hypertrophy, particularly in small arteries, in the deoxycorticosterone acetate-salt hypertensive model, suggesting a paracrine role for vascular Endothelin-1 in the induction of blood vesselhypertrophy in some forms of experimental hypertension.

Myocardial Fibrosis in DOCA-Salt Hypertensive Rats: Effect of Endothelin ETA Receptor Antagonism

The hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease, is supported.

Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats.

SHR may exhibit enhanced expression of the endothelin-1 gene in blood vessels when treated with DOCA and salt, and associated with this there is severe vascular hypertrophy, and these data support the hypothesis of a role of endothelins-1 in vascularhypertrophy.

Total peripheral conductance mediates antihypertensive effect of nonpeptide mixed endothelin receptor antagonist in deoxycorticosterone acetate-salt hypertensive rats.

Effect of chronic treatment with two different ETA selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats

Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats.

Results indicate that ET(B) receptors in the renal medulla are up-regulated in the DOCA-salt hypertensive rat and may serve to maintain a lower arterial pressure by promoting salt and water excretion.

Hemodynamic effects of a selective endothelin--a receptor antagonist in deoxycorticosterone acetate-salt hypertensive rats.

The results suggest that the role of ETA receptors in the maintenance of the hypertensive state in the DOCA-salt model of hypertension is exerted at the level of the resistance vessels and not on factors that regulate CO.
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31 References

Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats.

Significant morphological and functional changes in small arteries of DOCA-salt hypertensive rats within 2 wk of developing hypertension and blunted reactivity to ET-1 are demonstrated.

Endothelin vascular receptors and responses in deoxycorticosterone acetate-salt hypertensive rats.

The vasoconstrictor effect, the binding, and the response of inositol phosphates to endothelin-1 (ET-1) were investigated in blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats…

Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.

Investigating immunoreactive ET-1 levels in acid extracts from blood vessels of deoxycorticosterone acetate (DOCA)-salt and spontaneously hypertensive rats found that segments of thoracic aorta and the mesenteric vascular bed contain significantly more ir-ET-1 than uninephrectomized control rats, suggesting that ET- 1 may be involved in the maintenance of high blood pressure in mineralocorticoid hypertension.

Effect of Antihypertensive Treatment on Response to Endothelin of Resistance Arteries of Hypertensive Rats

It is concluded that effective blood pressure (BP) reduction results in regression of the morphologic changes of resistance arteries of 2-K, 1 C hypertensive rats and normalizes blunted responses to endothelin-1 and other agents in these blood vessels.

Effects of endothelin-1 and vasopressin on resistance arteries of spontaneously hypertensive rats.

The results demonstrate the presence of remodeling in resistance arteries of 20-week-old SHR, and show that the altered morphology of these blood vessels may significantly amplify impaired wall stress responses to endothelin-1 and arginine vasopressin, which may contribute to elevation of blood pressure.

Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients.

The results suggest that gluteal subcutaneous small resistance arteries of male essential hypertensive patients exhibit a decrement in responsiveness to endothelin-1, a potent vasoconstrictor peptide that may contribute to the maintenance of elevated blood pressure.

Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats.

Investigating preproendothelin-1 gene expression in blood vessels of DOCA-salt hypertensive rats and uninephrectomized control rats found a fourfold to fivefold increase in abundance of preproends RNA transcripts in both aorta and mesenteric arteries.

Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats.

Endothelin sensitivity and receptor binding in the aorta of spontaneously hypertensive rats.

The aim of this study was to determine whether sensitivity to endothelin was greater in isolated aortic rings of spontaneously hypertensive rats than in those of normotensive Wistar-Kyoto rats and, if so, whether this was due to an increased binding affinity.

Plasma immunoreactive endothelin in essential hypertension.

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