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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Single-cell nanocapsules of gut microbiota facilitate fecal microbiota transplantation
Weiliang Hou, Yuan Cao, Jifeng Wang, Fang Yin, Jiahui Wang, Ning Guo, Ziyi Wang, Xiaoqiong Lv, Chunlian Ma, Qiyi Chen, Rong Yang, Hong Wei, Juanjuan Li, Ruibing Wang, Huanlong Qin
Theranostics 2025; 15(5): 2069-2084. doi:10.7150/thno.104852
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Research Paper
Tumor-selective dye-based histological electrophoresis enables intraoperative tumor diagnosis via tumor-specific enhancement
Feiran Zhang, Jianing Cheng, Xu Peng, Chengbin Zhang, Limei Qu, Songling Zhang, Junhu Zhang, Shoujun Zhu
Theranostics 2025; 15(5): 2052-2068. doi:10.7150/thno.105500
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Research Paper
Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold
Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Nazereth Tan Chor Boon, Yiying Ma, Yiting Lim, Karlina Bte Jubri, Jingyi Hu, Jimin Yuan, Ge Zhang, Quan Li, Yoon Sim Yap, Paula Lam, Mei Wang, Naiyang Fu, Jiancheng Hu
Theranostics 2025; 15(5): 2035-2051. doi:10.7150/thno.103958
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Research Paper
Silybin A from Silybum marianum reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids
Solveigh C. Koeberle, Maria Thürmer, Fengting Su, Markus Werner, Julia Grander, Laura Hofer, André Gollowitzer, Loc Le Xuan, Felix J. Benscheid, Ehsan Bonyadi Rad, Armando Zarrelli, Giovanni Di Fabio, Oliver Werz, Valeria Romanucci, Amelie Lupp, Andreas Koeberle
Theranostics 2025; 15(5): 2006-2034. doi:10.7150/thno.99562
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Research Paper
Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4
Lihua Chen, Yuan Gao, Xinxin Hao, Xiaoxue Yang, Michelle Lindström, Shan Jiang, Xiuling Cao, Huisheng Liu, Thomas Nyström, Per Sunnerhagen, Beidong Liu
Theranostics 2025; 15(5): 1987-2005. doi:10.7150/thno.98199
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Research Paper
TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance
Zhi Liu, Chunyu Zhang, Jiatong Xiao, Yunbo He, Haisu Liang, Jinliang Huang, Zhiyong Cai, Zhenglin Yi, Mingfeng Chen, Yixiao Li, Jun Zhang, Fenglian liu, Peng Ren, Huihuang Li, Jinbo Chen, Benyi Fan, Jiao Hu, Xiongbing Zu, Dingshan Deng
Theranostics 2025; 15(5): 1966-1986. doi:10.7150/thno.103175
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

Background: Identifying biomarkers that predict immunotherapy efficacy and discovering new _targets for combination therapies are critical elements for improving the prognosis of bladder cancer (BLCA) patients. Methods: Firstly, we explored the expression patterns of TBX3 in normal and pan-cancer tissues and the correlation between TBX3 and the immune microenvironment using data from multiple public databases. Then, we combined various techniques, including bulk RNA sequencing, single-cell RNA sequencing, high-throughput cytokine arrays, functional experiments, ProcartaPlex multiplex immunoassays....
Rationale: Silybum marianum is used to protect against degenerative liver damage. The molecular mechanisms of its bioactive component, silybin, remained enigmatic, although membrane-stabilizing properties, modulation of membrane protein function, and metabolic regulation have been discussed for decades. Methods: Experiments were performed with hepatocyte cell lines and primary monocytes in vitro under both basal and stressed conditions, and in mice in vivo. Quantitative lipidomics was used to detect changes in phospholipids and triglycerides. Key findings were confirmed by Western blotting, quantitative....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Therapeutic Potential of Feline Adipose-Derived Stem Cell Exosomes in the Treatment of Feline Idiopathic Cystitis: A Characterization and Functional Analysis of miRNA Content
Andrea Rubini, Federica Zanotti, Danilo Licastro, Giulia Calogero, Gisella Bettini, Cristiana Piccoli, Giuseppe Rubini, Luca Lovatti, Barbara Zavan
Nanotheranostics 2025; 9(1): 38-51.
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