(Q28209496)

English

remdesivir

chemical compound and antiviral drug

  • GS-5734
  • 2-ethylbutyl (2S)-2-({[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl}amino)propanoate
  • Veklury
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Remdesivir.svg
512 × 432; 11 KB
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602.2253987099999 dalton
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C₂₇H₃₅N₆O₈P
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Nc3ncnn2c3ccc2C(C#N)(C1O)OC(C1O)CO[P](=O)(NC(C)C(=O)OCC(CC)CC)Oc4ccccc4
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CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
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1 reference
22 January 2022
The antiviral remdesivir should not be used as treatment for hospitalized Covid-19 patients, the World Health Organization said Thursday, only a month after the Food and Drug Administration approved the drug to treat patients over age 12 who are hospitalized with Covid-19. (English)
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22 January 2022
Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. (English)
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FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)
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22 January 2022
WHO has issued a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients. (English)
22 January 2022
However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups. (English)
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22 January 2022
Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. (English)
Remdesivir
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Identifiers

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EMEA/H/C/005622
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